4.5 Article

Retinal Blood Velocity Waveform Characteristics With Aging and Arterial Stiffening in Hypertensive and Normotensive Subjects

Journal

TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
Volume 10, Issue 13, Pages -

Publisher

ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/tvst.10.13.25

Keywords

retinal microcirculation; Doppler optical coherence tomography; retinal blood flow measurement; arteriosclerosis

Categories

Funding

  1. Ministry of Education, Science and Culture, Tokyo, Japan [19K18867]
  2. Grants-in-Aid for Scientific Research [19K18867] Funding Source: KAKEN

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The study explored velocity waveform characteristics of the retinal artery related to age and CAVI with DOCT flowmeter, finding UTc correlated positively with age, while area declination was negatively correlated with both age and CAVI. This indicates that DOCT flowmeter analysis could potentially offer a new method for identifying arterial stiffness beyond traditional pressure waveform measurement methods.
Purpose: We aimed to explore the velocity waveform characteristics of the retinal artery associated with age and the cardio-ankle vascular index (CAVI) as a conventional arterial stiffness marker by applying the Doppler optical coherence tomography (DOCT) flowmeter. Methods: In this cross-sectional study, DOCT flowmeter imaging was performed in 66 participants aged 21 to 83 years (17 men, 49 women) with no history of eye diseases and no systemic diseases, except for hypertension. Retinal blood velocity waveform was analyzed where several parameters in time (upstroke time, T1, T2, T3, and T4) and area under the waveform (area elevation, area declination, A1, A2, A3, and A4) were extracted. Systolic blood pressure-adjusted Pearson's coefficients were calculated to determine the correlations of each parameter with age or CAVI. Results: Corrected upstroke time (UTc) was the waveform parameter most positively correlated with age (r = 0.497, P < 0.001). Area declination was the waveform parameter most negatively correlated with age (r= -0.682, P < 0.001) and CAVI (r= -0.601, P < 0.001). Conclusions: We extracted the waveform parameters associated with the risks of arterial stiffening. The velocity waveform analysis of the retinal artery with DOCT flowmeter potentially could become a new method for arterial stiffness identification. Translational Relevance: DOCT flowmeter could evaluate arterial stiffening in a different way from the conventional method of measuring arterial stiffening using pressure waveform. Because the DOCT flowmeter can easily, quickly, and noninvasively provide a retinal blood velocity waveform, this system could be useful as a routine medical examination for arterial stiffening.

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