Journal
ROYAL SOCIETY OPEN SCIENCE
Volume 9, Issue 2, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsos.211642
Keywords
canine metabolism; canine physiology; nuclear magnetic resonance metabolomics; metabolites
Categories
Funding
- Academy of Finland [308887]
- PetBiomics Ltd.
- Academy of Finland (AKA) [308887, 308887] Funding Source: Academy of Finland (AKA)
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Metabolomics has vast potential in biomedical applications. Factors such as age, breed, sex, sterilization, diet type, and fasting time significantly affect the metabolite profiles of healthy pet dogs, with breed and age causing considerable variation in metabolite concentrations.
As an individual's metabolism reflects health and disease states well, metabolomics holds a vast potential in biomedical applications. However, normal physiological factors, such as age, can also influence metabolism, challenging the establishment of disease-specific metabolic aberrations. Here, we examined how physiological and diet-related factors drive variance in the metabolism of healthy pet dogs. We analysed 2068 serum samples using a canine nuclear magnetic resonance (NMR) spectroscopy-based metabolomics platform. With generalized linear models, we discovered that age, breed, sex, sterilization, diet type and fasting time significantly affected the canine metabolite profiles. Especially, breed and age caused considerable variation in the metabolite concentrations, and breeds with very different body conformations systematically differed in several lipid measurands. Our results enhance the understanding how normal physiological factors influence canine metabolism, aid accurate interpretation of the NMR results, and suggest the NMR platform might be applied in identifying aberrations in nutrient absorption and metabolism.
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