Sr3(PO4)2 particles as a factor for the formation of functional coating on titanium implant

The aim of this work is to analyze the usefulness of Sr-3(PO4)(2) as a potential antibacterial agent in fast-degradable polymer coatings. The Ti implant was anodized and then covered by a poly(adipic anhydride) layer blended with Sr-3(PO4)(2) particles by dip coating. The average size of the particles was 450 nm +/- 53 nm (Zetasizer analysis), and phase analysis (X-ray diffractometer) showed mainly crystalline phases. Surface morphology and surface roughness were analyzed by scanning electron microscopy with energy dispersive X-ray (EDX). The oxide layer thickness on the implant surface was between 4.57 am and 8.09 am. The polymer layer with Sr-3(PO4)(2) particles was determined by confocal microscopy, and the average thickness was 25 am. The contact angle of the anodized Ti implant alone was 37.3 degrees +/- 9.9 degrees and decreased with time up to 20 degrees after 1900s. After 1 h of implant immersion in Ringer solution, 42.15% of the Sr compound loaded in the polymer layer was released (determined by inductively coupled plasma atomic emission spectrometry (ICP-AES)). Fast degradation of the polymer caused 65.21% of the loaded Sr compound to be released from the implant surface after 24 h. The concentration of Sr-3(PO4)(2) was enough to significantly inhibit the adhesion of Staphylococcus aureus ATCC 25923 bacteria on the implant surface. The implant surface is cytocompatible with osteoblast-like MG-63 cells. The preliminary results of hybrid coating analysis showed that Sr-3(PO4)(2) may be used as an alternative ceramic material for the formation of a functional layer for orthopedic applications. (C) 2021 The Author(s). Published by Elsevier B.V.

Automated summary

The aim of this study was to analyze the usefulness of Sr-3(PO4)(2) as a potential antibacterial agent in fast-degradable polymer coatings. The results showed that the incorporation of Sr-3(PO4)(2) particles can significantly inhibit bacterial adhesion on the implant surface and the implant surface is cytocompatible with MG-63 cells.