Journal
CHEMNANOMAT
Volume 8, Issue 1, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cnma.202100443
Keywords
fluorescence; nanoparticle uptake; surface functionalization; lipophilicity
Categories
Funding
- National Center of Competence in Research (NCCR)
- Adolphe Merkle Foundation
- FCT (Fundacao para a Ciencia e Technologia) [2020.04021.CEECIND]
- Universite de Fribourg
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Fluorescently-labelled nanoparticles show promise for tracking and detection in biological applications, but the presence of fluorescent dyes can alter nanoparticle behavior, particularly affecting interactions with biomolecules and cellular uptake.
Fluorescently-labelled nanoparticles show great promise for nanoparticle tracking and detection in biological or medical applications. However, these fluorescent molecules functionalized on the surface of the nanoparticles can impact the interaction of nanoparticles with biomolecules, cells, and subsequently influence their uptake. To explore the extent of these interactions, PEGylated gold nanoparticles were functionalized with six structurally different fluorescent dyes to demonstrate that the presence of the dye alters nanoparticle behavior, in particular interactions with bovine serum albumin, which consequently influenced their cellular uptake.
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