The Role of NPY in the Regulation of Bone Metabolism

Bone diseases are the leading causes of disability and severely compromised quality of life. Neuropeptide Y (NPY) is a multifunctional neuropeptide that participates in various physiological and pathological processes and exists in both the nerve system and bone tissue. In bone tissue, it actively participates in bone metabolism and disease progression through its receptors. Previous studies have focused on the opposite effects of NPY on bone formation and resorption through paracrine modes. In this review, we present a brief overview of the progress made in this research field in recent times in order to provide reference for further understanding the regulatory mechanism of bone physiology and pathological metabolism.

Automated summary

Bone diseases are the main causes of disability and impaired quality of life. Neuropeptide Y plays important roles in bone tissue by regulating bone metabolism and disease progression through its receptors. This review provides a brief overview of recent progress in understanding the regulatory mechanism of bone physiology and pathological metabolism.