4.7 Review

The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application

Jafar Rezaie et al.

Summary: Eukaryotic cells produce extracellular vesicles (EVs) that mediate intercellular communication and are utilized by viruses like HIV-1 and HTLV-1 for spreading and infection. Exosomes from virus-infected cells have the potential to be used for vaccine development and early diagnosis of viral infections. Ongoing research on exosomes shed from virus-infected cells may provide insights into the mechanisms of pathogenesis associated with retroviruses.

CELL AND BIOSCIENCE (2021)

Review Genetics & Heredity

Current Status and Future Prospects of Perinatal Stem Cells

Paz de la Torre et al.

Summary: The placenta, a temporary organ discarded after birth, is a promising source of cells and tissues for regenerative medicine and tissue engineering. Different perinatal tissues contain various stem cells that can be used for cell therapy and regenerative medicine, with cord blood being the primary source. These perinatal stem cells have been used in clinical trials for over 30 years to treat various disorders, with a special focus on mesenchymal stromal cells. Research on the clinical applications and potential of perinatal derived cells is ongoing, particularly in the context of treating COVID19 pneumonia. Technologies in the field of perinatal stem cells are advancing rapidly, offering new opportunities and facing challenges.

GENES (2021)

Article Cell Biology

Plasma Exosomes Derived From Patients With End-Stage Renal Disease and Renal Transplant Recipients Have Different Effects on Vascular Calcification

Xiao Lin et al.

Summary: This study found that plasma exosomes from ESRD patients significantly promoted vascular smooth muscle cells calcification, while renal transplantation partially attenuated this procalcification effect. Fetuin-A and MGP were decreased, but Annexin-A2 was increased in ESRD-Ex, and renal transplantation could increase the level of Fetuin-A rather than MGP. The levels of Fetuin-A and MGP in plasma exosomes were negatively while the levels of Annexin-A2 in plasma exosomes were positively correlated to coronary artery calcification scores (CACS).

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Extracellular Vesicles From Epicardial Fat Facilitate Atrial Fibrillation

Olga Shaihov-Teper et al.

Summary: This study revealed, for the first time, a distinctive proinflammatory, profibrotic, and proarrhythmic signature of epicardial fat-derived extracellular vesicles in patients with atrial fibrillation, uncovering another pathway by which epicardial fat promotes the development of atrial myopathy and fibrillation.

CIRCULATION (2021)

Review Cell Biology

Exosomes and Obesity-Related Insulin Resistance

Li-Min Lei et al.

Summary: Exosomes are extracellular vesicles that play a crucial role in delivering signal molecules from donor cells to recipient cells, with a cargo that includes proteins, DNA, and RNA targeting recipient tissues and organs, influencing disease development. Research indicates that exosomes are significant in the development of insulin resistance caused by obesity, showing promise for diagnosis and therapy of insulin resistance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell & Tissue Engineering

Mesenchymal Stromal Cell-Derived Extracellular Vesicles in the Treatment of Diabetic Foot Ulcers: Application and Challenges

Tao An et al.

Summary: MSCs are considered as a promising cell-based therapy for diabetic foot ischemia and ulcer, as they can repair injured cells and promote wound healing. The secretomes of MSCs have immunomodulatory and regenerative effects, which are crucial for treating diabetes-induced lower limb ischemia and ulcers.

STEM CELL REVIEWS AND REPORTS (2021)

Article Biotechnology & Applied Microbiology

The effect of exosomes derived from mesenchymal stem cells in the treatment of induced type 1 diabetes mellitus in rats

Dina Sabry et al.

BIOTECHNOLOGY LETTERS (2020)

Review Medicine, Research & Experimental

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications

Mahdi Ahmadi et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Immunology

Proteomic Analysis of Exosome-Like Vesicles Isolated From Saliva of the Tick Haemaphysalis longicornis

Mohsin Nawaz et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Article Pharmacology & Pharmacy

Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides

Philip Grossen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

Review Oncology

Dexosomes as a cell-free vaccine for cancer immunotherapy

Sepideh Nikfarjam et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Review Medicine, Research & Experimental

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine

Sepideh Nikfarjam et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Review Biochemical Research Methods

Harnessing Exosomes for the Development of Brain Drug Delivery Systems

Mengna Zheng et al.

BIOCONJUGATE CHEMISTRY (2019)

Article Engineering, Biomedical

Mesenchymal stem cell-derived extracellular vesicles and retinal ischemia-reperfusion

Biji Mathew et al.

BIOMATERIALS (2019)

Article Oncology

Exosomes increased angiogenesis in papillary thyroid cancer microenvironment

Feng Wu et al.

ENDOCRINE-RELATED CANCER (2019)

Article Medicine, Research & Experimental

Effects of Localization of Antigen Proteins in Antigen-Loaded Exosomes on Efficiency of Antigen Presentation

Yuta Arima et al.

MOLECULAR PHARMACEUTICS (2019)

Article Biochemistry & Molecular Biology

Reassessment of Exosome Composition

Dennis K. Jeppesen et al.

Article Developmental Biology

Exosomes populate the cerebrospinal fluid of preterm infants with post-haemorrhagic hydrocephalus

Robert Spaull et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2019)

Review Biochemistry & Molecular Biology

Exosomes

D. Michiel Pegtel et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 88 (2019)

Article Medicine, Research & Experimental

Exosomal microRNA‐16‐5p from human urine‐derived stem cells ameliorates diabetic nephropathy through protection of podocyte

Yu‐Rui Duan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2019)

Review Oncology

Role of tumor-derived exosomes in bone metastasis

Fu-Xing-Zi Li et al.

ONCOLOGY LETTERS (2019)

Review Endocrinology & Metabolism

β-cell autophagy: Mechanism and role in β-cell dysfunction

Yong-ho Lee et al.

MOLECULAR METABOLISM (2019)

Review Pharmacology & Pharmacy

Exosomes and Bone Disease

Su-Kang Shan et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

Review Endocrinology & Metabolism

Exosomes and diabetes

Carlos Castano et al.

DIABETES-METABOLISM RESEARCH AND REVIEWS (2019)

Article Cell & Tissue Engineering

Promising effects of exosomes isolated from menstrual blood-derived mesenchymal stem cell on wound-healing process in diabetic mouse model

Razieh Dalirfardouei et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2019)

Review Urology & Nephrology

Stem Cell Therapy for Erectile Dysfunction

Ethan L. Matz et al.

SEXUAL MEDICINE REVIEWS (2019)

Article Biochemistry & Molecular Biology

Molecular aspects of diabetes mellitus: Resistin, microRNA, and exosome

Mohammad Javad Saeedi Borujeni et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Article Endocrinology & Metabolism

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

N. H. Cho et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Article Medicine, Research & Experimental

Thyroid cancer stem-like cell exosomes: regulation of EMT via transfer of lncRNAs

Heather Hardin et al.

LABORATORY INVESTIGATION (2018)

Review Biotechnology & Applied Microbiology

Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges

Luiza Bagno et al.

MOLECULAR THERAPY (2018)

Review Medicine, Research & Experimental

Exosome Theranostics: Biology and Translational Medicine

Chuanjiang He et al.

THERANOSTICS (2018)

Review Endocrinology & Metabolism

Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications

Bou-Yue Peng et al.

JOURNAL OF DIABETES RESEARCH (2018)

Review Cell & Tissue Engineering

Stem cells as delivery vehicles for regenerative medicine-challenges and perspectives

Luminita Labusca et al.

WORLD JOURNAL OF STEM CELLS (2018)

Article Biochemistry & Molecular Biology

High glucose condition limited the angiogenic/cardiogenic capacity of murine cardiac progenitor cells in in vitro and in vivo milieu

Majid Khaksar et al.

CELL BIOCHEMISTRY AND FUNCTION (2018)

Article Medicine, Research & Experimental

Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia

Na Zhang et al.

JCI INSIGHT (2018)

Review Endocrinology & Metabolism

Metabolomics window into diabetic complications

Tao Wu et al.

JOURNAL OF DIABETES INVESTIGATION (2018)

Article Cell Biology

Quantification of Exosomes

Erik H. Koritzinsky et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

Review Endocrinology & Metabolism

Stem cell-derived exosomes: a novel vector for tissue repair and diabetic therapy

William C. Newton et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2017)

Review Medicine, Research & Experimental

Progress in Exosome Isolation Techniques

Pin Li et al.

THERANOSTICS (2017)

Article Endocrinology & Metabolism

Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy

Luigi Rossi et al.

JOURNAL OF DIABETES RESEARCH (2017)

Article Multidisciplinary Sciences

Oestrogen Inhibits Arterial Calcification by Promoting Autophagy

Yi-Qun Peng et al.

SCIENTIFIC REPORTS (2017)

Review Medicine, Research & Experimental

Concise review: Extracellular vesicles from mesenchymal stem cells as cellular therapy

Phuc Van Pham

BIOMEDICAL RESEARCH AND THERAPY (2017)

Review Endocrinology & Metabolism

Exosomes as new players in metabolic organ cross-talk

Claudiane Guay et al.

DIABETES OBESITY & METABOLISM (2017)

Review Biochemistry & Molecular Biology

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases

Guohua Lou et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

Review Medicine, General & Internal

Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective

Francesco Zaccardi et al.

POSTGRADUATE MEDICAL JOURNAL (2016)

Article Engineering, Biomedical

Efficient production and enhanced tumor delivery of engineered extracellular vesicles

Dionysios C. Watson et al.

BIOMATERIALS (2016)

Review Cell & Tissue Engineering

Clinical Trials With Mesenchymal Stem Cells: An Update

Tiziana Squillaro et al.

CELL TRANSPLANTATION (2016)

Review Biotechnology & Applied Microbiology

Exosomes for repair, regeneration and rejuvenation

Joydeep Basu et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2016)

Article Cell Biology

Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155

Yaqin Zhang et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2016)

Article Cell & Tissue Engineering

Exosomes secreted by human urine-derived stem cells could prevent kidney complications from type I diabetes in rats

Zhen-zhen Jiang et al.

STEM CELL RESEARCH & THERAPY (2016)

Article Cell & Tissue Engineering

miR-145 Regulates Diabetes-Bone Marrow Stromal Cell-Induced Neurorestorative Effects in Diabetes Stroke Rats

Chengcheng Cui et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

Review Endocrinology & Metabolism

Current Challenges in Diabetic Nephropathy: Early Diagnosis and Ways to Improve Outcomes

Sang Soo Kim et al.

ENDOCRINOLOGY AND METABOLISM (2016)

Article Biochemistry & Molecular Biology

Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice

Adolf Geiger et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Radiology, Nuclear Medicine & Medical Imaging

Correlation of the Strength of Recommendations for Additional Imaging to Adherence Rate and Diagnostic Yield

H. Benjamin Harvey et al.

JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY (2015)

Article Cell Biology

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Thomas Lener et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Review Endocrinology & Metabolism

Literature review on the management of diabetic foot ulcer

Leila Yazdanpanah et al.

WORLD JOURNAL OF DIABETES (2015)

Article Endocrinology & Metabolism

Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment

Steven F. Abcouwer et al.

YEAR IN DIABETES AND OBESITY (2014)

Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Biochemistry & Molecular Biology

NFkappaB activation is essential for miR-21 induction by TGFβ1 in high glucose conditions

Radha Madhyastha et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Review Endocrinology & Metabolism

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

Nathalie Esser et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2014)

Article Cardiac & Cardiovascular Systems

Advanced glycation end products: role in pathology of diabetic cardiomyopathy

Vijaya Lakshmi Bodiga et al.

HEART FAILURE REVIEWS (2014)

Review Biochemistry & Molecular Biology

Exosomes Derived from Mesenchymal Stem Cells

Bo Yu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2014)

Article Medicine, General & Internal

Type 1 diabetes

Mark A. Atkinson et al.

LANCET (2014)

Article Biotechnology & Applied Microbiology

Mesenchymal stem cells: immune evasive, not immune privileged

James A. Ankrum et al.

NATURE BIOTECHNOLOGY (2014)

Article Endocrinology & Metabolism

Human Adipocyte Extracellular Vesicles in Reciprocal Signaling Between Adipocytes and Macrophages

Mariette E. G. Kranendonk et al.

OBESITY (2014)

Article Dermatology

Bone marrow-derived mesenchymal stem cell attenuates skin fibrosis development in mice

Yan Wu et al.

INTERNATIONAL WOUND JOURNAL (2014)

Review Pharmacology & Pharmacy

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

Ronne Wee Yeh Yeo et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Article Endocrinology & Metabolism

MiR-133a Modulates Osteogenic Differentiation of Vascular Smooth Muscle Cells

Xiao-Bo Liao et al.

ENDOCRINOLOGY (2013)

Article Multidisciplinary Sciences

Urinary Exosomal MicroRNAs in Incipient Diabetic Nephropathy

Federica Barutta et al.

PLOS ONE (2013)

Article Cell & Tissue Engineering

Transfer of Growth Factor Receptor mRNA Via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells

Susanna Tomasoni et al.

STEM CELLS AND DEVELOPMENT (2013)

Article Medicine, Research & Experimental

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

Jessian L. Munoz et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2013)

Article Cell & Tissue Engineering

Microvesicles Derived From Endothelial Progenitor Cells Enhance Neoangiogenesis of Human Pancreatic Islets

Vincenzo Cantaluppi et al.

CELL TRANSPLANTATION (2012)

Article Biochemistry & Molecular Biology

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

Yi Lee et al.

HUMAN MOLECULAR GENETICS (2012)

Article Biochemical Research Methods

Long-term, efficient inhibition of microRNRNA function in mice using rAAV vectors

Jun Xie et al.

NATURE METHODS (2012)

Article Cardiac & Cardiovascular Systems

Mesenchymal stem cells overexpressing MiR-126 enhance ischemic angiogenesis via the AKT/ERK-related pathway

Jian-Jun Chen et al.

CARDIOLOGY JOURNAL (2011)

Review Endocrinology & Metabolism

Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management

Vrushali S. Thorve et al.

JOURNAL OF DIABETES AND ITS COMPLICATIONS (2011)

Article Biotechnology & Applied Microbiology

Paracrine Factors of Multipotent Stromal Cells Ameliorate Lung Injury in an Elastase-induced Emphysema Model

Ahmed M. Katsha et al.

MOLECULAR THERAPY (2011)

Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

Article Multidisciplinary Sciences

Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23∼27∼24 clusters

Qinbo Zhou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Cell & Tissue Engineering

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

Ruenn Chai Lai et al.

REGENERATIVE MEDICINE (2011)

Article Cell & Tissue Engineering

Defining the risks of mesenchymal stromal cell therapy

Darwin J. Prockop et al.

CYTOTHERAPY (2010)

Review Biochemistry & Molecular Biology

A look inside the diabetic brain: Contributors to diabetes-induced brain aging

Shayna A. Wrighten et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Review Clinical Neurology

Diabetic neuropathy - a review

Gerard Said

NATURE CLINICAL PRACTICE NEUROLOGY (2007)

Review Multidisciplinary Sciences

Biochemistry and molecular cell biology of diabetic complications

M Brownlee

NATURE (2001)