Journal
INFECTION AND DRUG RESISTANCE
Volume 14, Issue -, Pages 5351-5361Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S341591
Keywords
bacteriemia; Janibacter; genomic sequencing
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Funding
- Science and Technology Plan Project of the Health Commission of Jiangxi Province [20203655]
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This study reported the first isolation of the rare bacterial infection Janibacter from a bacteremia patient in China, identified as Janibacter YFY001 belonging to J. indicus. Through genome sequencing, many virulence factors and resistance genes were identified, as well as three genomic islands in YFY001 when compared to environmental Janibacter strains.
Introduction: Janibacter caused bacteriemia is one of the rare infections. Methods: In the present study, we report the first isolation of Janibacter, a rare bacterial infection, from a bacteremia patient in China. Its 16S rDNA was amplified and designated as Janibacter YFY001, which belongs to J. indicus. In addition, its genome was sequenced through combined second-and third-generation genome sequencing methods. Results: Based on its genome, we identified many virulence factors, such as catalase, gelatinase, FbpABC systems, and resistant genes, among others. Interestingly, three genomic islands were found in YFY001 by comparing its genome to environmental Janibacter strains. Discussion: Our study not only provides the necessary genomic information for in-depth study of Janibacter, but also provides a novel methodology for studying future cases of rare bacterial infection.
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