Cognitive Process of Psoriasis and Its Comorbidities: From Epidemiology to Genetics

Psoriasis (PsO) is a chronic inflammatory skin disease that affects approximately 2% of the population all over the world. Comorbidities of PsO have increasingly garnered more interest in the past decades. Compared with the normal population, the incidences of comorbidities are higher among patients with PsO. In the last 20 years, researchers have focused on studying the genetic components of PsO, and genetic associations between PsO and its comorbidities were elucidated. This review provides an in-depth understanding and summarization of the connection between PsO and its comorbidities from the perspectives of epidemiology and genetics. Further understanding of PsO and its comorbidities will promote research on the pathogenesis, drug development, novel therapy methods, and personalized and precision treatment of PsO and its comorbidities.

Automated summary

Psoriasis (PsO) is a chronic inflammatory skin disease affecting approximately 2% of the global population. The incidence of comorbidities in PsO patients is higher compared to the normal population. Research over the past 20 years on the genetic components of PsO has provided insight into the genetic associations between PsO and its comorbidities, leading to further understanding and potential advancements in drug development and treatment methods for PsO and its comorbidities.