Related references
Note: Only part of the references are listed.Control of the chromatin response to DNA damage: Histone proteins pull the strings
Juliette Ferrand et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)
RNA and liquid-liquid phase separation
Qi Guo et al.
NON-CODING RNA RESEARCH (2021)
TopBP1 assembles nuclear condensates to switch on ATR signaling
Camilla Frattini et al.
MOLECULAR CELL (2021)
Loop extrusion mediates physiological Igh locus contraction for RAG scanning
Hai-Qiang Dai et al.
NATURE (2021)
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency
Ji-Hoon Lee et al.
MOLECULAR CELL (2021)
Loop extrusion as a mechanism for formation of DNA damage repair foci
Coline Arnould et al.
NATURE (2021)
Chromatin mobility and relocation in DNA repair
Noa Lamm et al.
TRENDS IN CELL BIOLOGY (2021)
Single molecule microscopy reveals key physical features of repair foci in living cells
Judith Mine-Hattab et al.
ELIFE (2021)
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance
Ruben Schep et al.
MOLECULAR CELL (2021)
Genome folding through loop extrusion by SMC complexes
Iain F. Davidson et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)
Replication timing maintains the global epigenetic state in human cells
Kyle N. Klein et al.
SCIENCE (2021)
MacroH2A1 Regulation of Poly(ADP-Ribose) Synthesis and Stability Prevents Necrosis and Promotes DNA Repair
Penelope D. Ruiz et al.
MOLECULAR AND CELLULAR BIOLOGY (2020)
EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
Sergey Karakashev et al.
CANCER CELL (2020)
PARPs and ADP-ribosylation: 60 years on
W. Lee Kraus
GENES & DEVELOPMENT (2020)
Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation
Fabian Erdel et al.
MOLECULAR CELL (2020)
Methods for mapping 3D chromosome architecture
Rieke Kempfer et al.
NATURE REVIEWS GENETICS (2020)
DNA repair by Rad52 liquid droplets
Roxanne Oshidari et al.
NATURE COMMUNICATIONS (2020)
Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association
Jenna M. Whalen et al.
CELL REPORTS (2020)
Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
Robin Sebastian et al.
MOLECULAR CELL (2020)
The Self-Organizing Genome: Principles of Genome Architecture and Function
Tom Misteli
CELL (2020)
CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning
Zhaoqing Ba et al.
NATURE (2020)
Expanded encyclopaedias of DNA elements in the human and mouse genomes
Jill E. Moore et al.
NATURE (2020)
RNA: a double-edged sword in genome maintenance
Dali Zong et al.
NATURE REVIEWS GENETICS (2020)
3D genome organization contributes to genome instability at fragile sites
Dan Sarni et al.
NATURE COMMUNICATIONS (2020)
DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain
Jing Zhang et al.
NATURE COMMUNICATIONS (2020)
Complex Chromatin Motions for DNA Repair
Judith Mine-Hattab et al.
FRONTIERS IN GENETICS (2020)
Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress
Noa Lamm et al.
NATURE CELL BIOLOGY (2020)
Radiation-induced DNA damage and repair effects on 3D genome organization
Jacob T. Sanders et al.
NATURE COMMUNICATIONS (2020)
The cerebellar degeneration in ataxia-telangiectasia: A case for genome instability
Yosef Shiloh
DNA REPAIR (2020)
The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal
Karol Kramarz et al.
NATURE COMMUNICATIONS (2020)
R-Loops in Motor Neuron Diseases
Martina G. L. Perego et al.
MOLECULAR NEUROBIOLOGY (2019)
Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization
Elizabeth H. Finn et al.
CELL (2019)
53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage
Julian Spies et al.
NATURE CELL BIOLOGY (2019)
PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA
Anastasia S. Singatulina et al.
CELL REPORTS (2019)
Principles of genome folding into topologically associating domains
Quentin Szabo et al.
SCIENCE ADVANCES (2019)
Physical principles and functional consequences of nuclear compartmentalization in budding yeast
Judith Mine-Hattab et al.
CURRENT OPINION IN CELL BIOLOGY (2019)
Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments
Sinan Kilic et al.
EMBO JOURNAL (2019)
Assembling nuclear domains: Lessons from DNA repair
Benjamin Schrank et al.
JOURNAL OF CELL BIOLOGY (2019)
Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations
Henrike Johanna Gothe et al.
MOLECULAR CELL (2019)
Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity
Andres Canela et al.
MOLECULAR CELL (2019)
DNA double-strand break repair-pathway choice in somatic mammalian cells
Ralph Scully et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism
Liang Wang et al.
MOLECULAR CELL (2019)
The fundamental role of chromatin loop extrusion in physiological V(D)J recombination
Yu Zhang et al.
NATURE (2019)
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
Fabio Pessina et al.
NATURE CELL BIOLOGY (2019)
Control of DNA replication timing in the 3D genome
Claire Marchal et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Organization of Chromatin by Intrinsic and Regulated Phase Separation
Bryan A. Gibson et al.
CELL (2019)
Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences
David T. McSwiggen et al.
GENES & DEVELOPMENT (2019)
HP1 reshapes nucleosome core to promote phase separation of heterochromatin
S. Sanulli et al.
NATURE (2019)
Fundamental roles of chromatin loop extrusion in antibody class switching
Xuefei Zhang et al.
NATURE (2019)
Stabilization of chromatin topology safeguards genome integrity
Fena Ochs et al.
NATURE (2019)
DNA loop extrusion by human cohesin
Iain F. Davidson et al.
SCIENCE (2019)
Organization of Chromosomal DNA by SMC Complexes
Stanislau Yatskevich et al.
Annual Review of Genetics (2019)
Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
Cornelia Meisenberg et al.
MOLECULAR CELL (2019)
Individuals with &ITFANCM&IT biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility
Irene Catucci et al.
GENETICS IN MEDICINE (2018)
Recent evidence that TADs and chromatin loops are dynamic structures
Anders S. Hansen et al.
NUCLEUS (2018)
Recent evidence that TADs and chromatin loops are dynamic structures
Anders S. Hansen et al.
NUCLEUS (2018)
The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation
Adam G. Larson et al.
BIOCHEMISTRY (2018)
Formation of Chromatin Subcompartments by Phase Separation
Fabian Erdel et al.
BIOPHYSICAL JOURNAL (2018)
Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
Jeongkyu Kim et al.
MOLECULAR CELL (2018)
mRNA structure determines specificity of a polyQ-driven phase separation
Erin M. Langdon et al.
SCIENCE (2018)
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Won-Ki Cho et al.
SCIENCE (2018)
Real-time imaging of DNA loop extrusion by condensin
Mahipal Ganji et al.
SCIENCE (2018)
ATM directs DNA damage responses and proteostasis via genetically separable pathways
Ji-Hoon Lee et al.
SCIENCE SIGNALING (2018)
Protein Phase Separation: A New Phase in Cell Biology
Steven Boeynaems et al.
TRENDS IN CELL BIOLOGY (2018)
Nuclear microtubule filaments mediate non-linear directional motion of chromatin and promote DNA repair
Roxanne Oshidari et al.
NATURE COMMUNICATIONS (2018)
ATM directs DNA damage responses and proteostasis via genetically separable pathways
Ji-Hoon Lee et al.
SCIENCE SIGNALING (2018)
Heterochromatin: Guardian of the Genome
Aniek Janssen et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 34 (2018)
Shelterin-Mediated Telomere Protection
Titia de Lange
ANNUAL REVIEW OF GENETICS, VOL 52 (2018)
Nuclear F-actin and myosins drive relocalization of heterochromatic breaks
Christopher P. Caridi et al.
NATURE (2018)
Nuclear ARP2/3 drives DNA break clustering for homology-directed repair
Benjamin R. Schrank et al.
NATURE (2018)
Organizational principles of 3D genome architecture
M. Jordan Rowley et al.
NATURE REVIEWS GENETICS (2018)
Inherited DNA lesions determine G1 duration in the next cell cycle
Aleksandra Lezaja et al.
CELL CYCLE (2018)
Order from clutter: selective interactions at mammalian replication origins
Mirit I. Aladjem et al.
NATURE REVIEWS GENETICS (2017)
Chromatin and nucleosome dynamics in DNA damage and repair
Michael H. Hauer et al.
GENES & DEVELOPMENT (2017)
Phase separation drives heterochromatin domain formation
Amy R. Strom et al.
NATURE (2017)
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin
Adam G. Larson et al.
NATURE (2017)
EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation
Beatrice Rondinelli et al.
NATURE CELL BIOLOGY (2017)
The control of DNA repair by the cell cycle
Nicole Hustedt et al.
NATURE CELL BIOLOGY (2017)
Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism
John J. Reynolds et al.
NATURE GENETICS (2017)
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Howard H. Y. Chang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Arnab Ray Chaudhuri et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Biomolecular condensates: organizers of cellular biochemistry
Salman F. Banani et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes
Francois Aymard et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Genome maintenance in Saccharomyces cerevisiae: the role of SUMO and SUMO-targeted ubiquitin ligases
Deena Jalal et al.
NUCLEIC ACIDS RESEARCH (2017)
DNA replication through a chromatin environment
James M. Bellush et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)
Transcription-associated events affecting genomic integrity
Robin Sebastian et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)
PARP inhibitors: Synthetic lethality in the clinic
Christopher J. Lord et al.
SCIENCE (2017)
Identification of the elementary structural units of the DNA damage response
Francesco Natale et al.
NATURE COMMUNICATIONS (2017)
Genome-wide mapping of long-range contacts unveils clustering of DNA double-strand breaks at damaged active genes
Francois Aymard et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
A Cell-Line-Specific Atlas of PARP-Mediated Protein Asp/Glu-ADP-Ribosylation in Breast Cancer
Yuanli Zhen et al.
CELL REPORTS (2017)
Initiation of DNA replication requires actin dynamics and formin activity
Nikolaos Parisis et al.
EMBO JOURNAL (2017)
Structure of FUS Protein Fibrils and Its Relevance to Self-Assembly and Phase Separation of Low-Complexity Domains
Dylan T. Murray et al.
CELL (2017)
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity
Zachary Monahan et al.
EMBO JOURNAL (2017)
Cohesin Loss Eliminates All Loop Domains
Suhas S. P. Rao et al.
CELL (2017)
Poetry in motion: Increased chromosomal mobility after DNA damage
Michael J. Smith et al.
DNA REPAIR (2017)
Genome Organization Drives Chromosome Fragility
Andres Canela et al.
CELL (2017)
A Phase Separation Model for Transcriptional Control
Denes Hnisz et al.
CELL (2017)
Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets
Yongdae Shin et al.
CELL (2017)
Emerging Evidence of Chromosome Folding by Loop Extrusion
Geoffrey Fudenberg et al.
CHROMOSOME SEGREGATION AND STRUCTURE, VOL 82, 2017 (2017)
Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair
Corina Ohle et al.
CELL (2016)
The 3D Genome as Moderator of Chromosomal Communication
Job Dekker et al.
CELL (2016)
Nuclear compartmentalization of DNA repair
Alkmini Kalousi et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2016)
RNA-Based Coacervates as a Model for Membraneless Organelles: Formation, Properties, and Interfacial Liposome Assembly
William M. Aumiller et al.
LANGMUIR (2016)
Epigenome Maintenance in Response to DNA Damage
Juliette Dabin et al.
MOLECULAR CELL (2016)
Temporal and Spatial Uncoupling of DNA Double Strand Break Repair Pathways within Mammalian Heterochromatin
Katerina Tsouroula et al.
MOLECULAR CELL (2016)
Break-induced telomere synthesis underlies alternative telomere maintenance
Robert L. Dilley et al.
NATURE (2016)
Relocalization of DNA lesions to the nuclear pore complex
Catherine H. Freudenreich et al.
FEMS YEAST RESEARCH (2016)
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
Liis Uuskula-Reimand et al.
GENOME BIOLOGY (2016)
The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion
Guramrit Singh et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 84 (2015)
53BP1 and the LINC Complex Promote Microtubule-Dependent DSB Mobility and DNA Repair
Francisca Lottersberger et al.
CELL (2015)
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
Avinash Patel et al.
CELL (2015)
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes
Ram Madabhushi et al.
CELL (2015)
Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
Yuan Lin et al.
MOLECULAR CELL (2015)
Heterochromatic breaks move to the nuclear periphery to continue recombinational repair
Taehyun Ryu et al.
NATURE CELL BIOLOGY (2015)
SETDB1, HP1 and SUV39 promote repositioning of 53BP1 to extend resection during homologous recombination in G2 cells
Meryem Alagoz et al.
NUCLEIC ACIDS RESEARCH (2015)
Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process
Daniel K. C. Chung et al.
NATURE COMMUNICATIONS (2015)
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Matthias Altmeyer et al.
NATURE COMMUNICATIONS (2015)
DNA damage induces nuclear actin filament assembly by Formin-2 and Spire-1/2 that promotes efficient DNA repair
Brittany J. Belin et al.
ELIFE (2015)
Chromatin dynamics at DNA breaks: what, how and why?
Theo Lebeaupin et al.
AIMS BIOPHYSICS (2015)
Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis
Nam Woo Cho et al.
CELL (2014)
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping
Suhas S. P. Rao et al.
CELL (2014)
A systematic description of MLL fusion gene formation
Rebecca L. Wright et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2014)
Topologically associating domains are stable units of replication-timing regulation
Benjamin D. Pope et al.
NATURE (2014)
The biogenesis of chromosome translocations
Vassilis Roukos et al.
NATURE CELL BIOLOGY (2014)
MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation
Hongshan Chen et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
Francois Aymard et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal
Sebastien Britton et al.
NUCLEIC ACIDS RESEARCH (2014)
An optimized optogenetic clustering tool for probing protein interaction and function
Amir Taslimi et al.
NATURE COMMUNICATIONS (2014)
A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance
Simran Khurana et al.
CELL REPORTS (2014)
Transcription-Associated R-Loop Formation across the Human FMR1 CGG-Repeat Region
Erick W. Loomis et al.
PLOS GENETICS (2014)
The Chromatin Response to DNA Breaks: Leaving a Mark on Genome Integrity
Godelieve Smeenk et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 82 (2013)
The Spatial Organization of the Human Genome
Wendy A. Bickmore
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 14 (2013)
Chromatin Remodeling at DNA Double-Strand Breaks
Brendan D. Price et al.
CELL (2013)
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms
Joshua A. Regal et al.
HUMAN MOLECULAR GENETICS (2013)
Recombination-restarted replication makes inverted chromosome fusions at inverted repeats
Ken'Ichi Mizuno et al.
NATURE (2013)
Spatial Dynamics of Chromosome Translocations in Living Cells
Vassilis Roukos et al.
SCIENCE (2013)
Repair of Strand Breaks by Homologous Recombination
Maria Jasin et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
The homologous recombination machinery modulates the formation of RNA-DNA hybrids and associated chromosome instability
Lamia Wahba et al.
ELIFE (2013)
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes
Ofir Hakim et al.
NATURE (2012)
Site-specific DICER and DROSHA RNA products control the DNA-damage response
Sofia Francia et al.
NATURE (2012)
Increased chromosome mobility facilitates homology search during recombination
Judith Mine-Hattab et al.
NATURE CELL BIOLOGY (2012)
Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery
Vincent Dion et al.
NATURE CELL BIOLOGY (2012)
Cohesin Protects Genes against γH2AX Induced by DNA Double-Strand Breaks
Pierre Caron et al.
PLOS GENETICS (2012)
Double-Strand Break End Resection and Repair Pathway Choice
Lorraine S. Symington et al.
ANNUAL REVIEW OF GENETICS, VOL 45 (2011)
Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair
Irene Chiolo et al.
CELL (2011)
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Sophie E. Polo et al.
GENES & DEVELOPMENT (2011)
Replication stress induces 53BP1-containing OPT domains in G1 cells
Jeanine A. Harrigan et al.
JOURNAL OF CELL BIOLOGY (2011)
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
Claudia Lukas et al.
NATURE CELL BIOLOGY (2011)
High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome
Jason S. Iacovoni et al.
EMBO JOURNAL (2010)
Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange
Sarah Lambert et al.
MOLECULAR CELL (2010)
Cohesin Is Limiting for the Suppression of DNA Damage-Induced Recombination between Homologous Chromosomes
Shay Covo et al.
PLOS GENETICS (2010)
Epigenetic Silencing of the p16INK4a Tumor Suppressor Is Associated with Loss of CTCF Binding and a Chromatin Boundary
Michael Witcher et al.
MOLECULAR CELL (2009)
Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
Clifford P. Brangwynne et al.
SCIENCE (2009)
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
Nadya Dimitrova et al.
NATURE (2008)
Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase
Shigeki Nagai et al.
SCIENCE (2008)
Positional stability of single double-strand breaks in mammalian cells
Evi Soutoglou et al.
NATURE CELL BIOLOGY (2007)
Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks
Patrick Ryan Potts et al.
EMBO JOURNAL (2006)
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
MJ Kruhlak et al.
JOURNAL OF CELL BIOLOGY (2006)
Cajal bodies, nucleoli, and speckles in the Xenopus oocyte nucleus have a low-density, sponge-like structure
KE Handwerger et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2
MC Moreira et al.
NATURE GENETICS (2004)
Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains
JA Aten et al.
SCIENCE (2004)
Ataxia-telangiectasia-like disorder (ATLD) - its clinical presentation and molecular basis
AMR Taylor et al.
DNA REPAIR (2004)
Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair
L Ström et al.
MOLECULAR CELL (2004)
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain
E Ünal et al.
MOLECULAR CELL (2004)
Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre
M Lisby et al.
NATURE CELL BIOLOGY (2003)