Journal
FRONTIERS IN CHEMISTRY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2022.847929
Keywords
indocyanine green; lymph vessel; mesoporous silicon; LYVE-1; hyaluronic acid
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Funding
- Department of Education of Jilin Province
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The lymphatic system is crucial for the immune system's response to disease. Researchers have developed a biodegradable lymphatic targeting imaging agent based on the ICG-mesoporous silicon system, which has selectivity and long residence time.
The lymphatic system plays a crucial role in the immune system's recognition and response to disease. Therefore, the imaging of the lymphatic system, especially lymphatic vessels, has emerged as a valuable tool for the diagnosis of metastasis. FDA-approved small-molecule dyes, namely, indocyanine green (ICG), have been widely applied to lymphatic vessels imaging. However, due to the small physical size, such molecule-based agents show no selectivity, and rapid clearance from lymph nodes. Herein, a biodegradable lymphatic targeting imaging agent based on the ICG-mesoporous silicon system (ICG@HMONs-HA) was obtained, which not only could target lymph vessels but also had a long residence time. The reported work provides a practical way for lymph vessel fluorescence imaging and paves the way for clinical translation of nanomaterial-based tracers.
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