One-Pot Three-Component Coupling Reaction of α-Amino Aryl Ketones, Indoles, and Perbromomethane Under Mild Conditions

A simple and efficient one-pot three-component cascade reaction of alpha-amino aryl ketones, indoles, and CBr4 in moderate to good yields has been developed. This new strategy exhibits excellent mild reaction conditions and step-economy, easily accessible reactants, and simultaneous construction of three different new bonds (C=N, C-C, and N-Br) in a single step. It is worth noting that the protocol developed provides a simple and practical tool for the construction of diverse indole-containing heterocyclic frameworks, indicating its potential applications in medicinal and material chemistry.

Automated summary

A simple and efficient one-pot three-component cascade reaction has been developed using alpha-amino aryl ketones, indoles, and CBr4, resulting in moderate to good yields. This new strategy offers mild reaction conditions and step-economy, with easily accessible reactants and the simultaneous construction of three different new bonds (C=N, C-C, and N-Br) in a single step. The protocol developed provides a simple and practical tool for constructing diverse indole-containing heterocyclic frameworks, indicating its potential applications in medicinal and material chemistry.