Journal
FRONTIERS IN CHEMISTRY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2022.825772
Keywords
one-pot three-component; a-amino aryl ketones; indoles and perbromomethane; step-economy; C-H bond functionalization
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Funding
- National Natural Science Foundation of China [21502049, 51573040]
- Hunan Provincial Natural Science Foundation of China [2018JJ2032]
- Planned Science and Technology Project of Hunan Province, China [2015WK3003]
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A simple and efficient one-pot three-component cascade reaction has been developed using alpha-amino aryl ketones, indoles, and CBr4, resulting in moderate to good yields. This new strategy offers mild reaction conditions and step-economy, with easily accessible reactants and the simultaneous construction of three different new bonds (C=N, C-C, and N-Br) in a single step. The protocol developed provides a simple and practical tool for constructing diverse indole-containing heterocyclic frameworks, indicating its potential applications in medicinal and material chemistry.
A simple and efficient one-pot three-component cascade reaction of alpha-amino aryl ketones, indoles, and CBr4 in moderate to good yields has been developed. This new strategy exhibits excellent mild reaction conditions and step-economy, easily accessible reactants, and simultaneous construction of three different new bonds (C=N, C-C, and N-Br) in a single step. It is worth noting that the protocol developed provides a simple and practical tool for the construction of diverse indole-containing heterocyclic frameworks, indicating its potential applications in medicinal and material chemistry.
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