4.6 Article

Therapeutic Effect of Novel Cyanopyrrolidine-Based Prolyl Oligopeptidase Inhibitors in Rat Models of Amnesia

Related references

Note: Only part of the references are listed.
Article Neurosciences

Lacidipine Prevents Scopolamine-Induced Memory Impairment by Reducing Brain Oxido-nitrosative Stress in Mice

Kunal Khurana et al.

Summary: The study found that lacidipine can prevent memory impairment in a mouse model of Alzheimer's disease, reduce oxidative stress, and acetylcholinesterase activity. However, the improvement of memory and redox balance by lacidipine was attenuated in the presence of Bay-K8644.

NEUROTOXICITY RESEARCH (2021)

Review Geriatrics & Gerontology

Alpha-Synuclein as a Biomarker of Parkinson's Disease: Good, but Not Good Enough

Upasana Ganguly et al.

Summary: Parkinson's disease is the second most common neurodegenerative disorder in the elderly, primarily characterized by motor impairment. The lack of a definitive biomarker for PD has led researchers to focus on the potential role of alpha-synuclein as a key protein in the pathogenesis of the disease. Studies have shown promise in measuring different forms of alpha-synuclein in body fluids and peripheral tissues as a potential biomarker for PD, although methodological issues still need to be addressed through further research.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Oncology

KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation

Sarah Adriana Scuderi et al.

Summary: Glioblastoma (GB) is the most aggressive tumor of the central nervous system, with a low survival rate. The inhibitor KYP-2047 may serve as a potential therapeutic treatment to suppress or reduce GB progression by modulating angiogenesis and apoptosis pathways.

CANCERS (2021)

Article Pharmacology & Pharmacy

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

Reinis Svarcbahs et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Biochemistry & Molecular Biology

Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applications

Adela Simkova et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)

Article Medicine, Research & Experimental

The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy

Tommi P. Kilpelainen et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Biochemistry & Molecular Biology

The Effect of Cyanopyrrolidine Derivatives on the Activity of Prolyl Endopeptidase, Acute Exudative Inflammation and Visceral Pain in Mice

E. A. Ivanova et al.

BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY (2020)

Article Pharmacology & Pharmacy

Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target

Teemu A. Natunen et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2019)

Review Pharmacology & Pharmacy

New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases

Reinis Svarcbahs et al.

BIOCHEMICAL PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Prolyl oligopeptidase regulates progesterone secretion via the ERK signaling pathway in murine luteal cells

Ping Xu et al.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2019)

Article Chemistry, Medicinal

Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors

Tommi P. Kilpelainen et al.

ACS MEDICINAL CHEMISTRY LETTERS (2019)

Article Biochemistry & Molecular Biology

Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics

Salvador Guardiola et al.

CELL CHEMICAL BIOLOGY (2018)

Review Clinical Neurology

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

Valeria Calsolaro et al.

ALZHEIMERS & DEMENTIA (2016)

Article Biochemistry & Molecular Biology

Prolyl Oligopeptidase Enhances α-Synuclein Dimerization via Direct Protein-Protein Interaction

Mari H. Savolainen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Chemistry, Organic

Solution phase synthetic approach to fellutamide B

Jhillu Singh Yadav et al.

TETRAHEDRON LETTERS (2015)

Article Pharmacology & Pharmacy

KYP-2047 Penetrates Mouse Brain and Effectively Inhibits Mouse Prolyl Oligopeptidase

Aaro J. Jalkanen et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)

Article Chemistry, Medicinal

iLOGP: A Simple, Robust, and Efficient Description of n-Octanol/Water Partition Coefficient for Drug Design Using the GB/SA Approach

Antoine Daina et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)

Review Neurosciences

Protein phosphatase 2A dysfunction in Alzheimer's disease

Jean-Marie Sontag et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)

Article Medicine, Research & Experimental

Effect of Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on the Course of Experimental Depressive Syndrome in Rats

N. N. Khlebnikova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2013)

Article Medicine, Research & Experimental

Changes in Activity of Proline-Specific Peptidases in Rat Model for Dementia of Alzheimer's Type

G. A. Nazarova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2012)

Article Agriculture, Multidisciplinary

Design, Synthesis, and Antiviral Activity Evaluation of Phenanthrene-Based Antofine Derivatives

Ziwen Wang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Computational Prediction of Blood-Brain Barrier Permeability Using Decision Tree Induction

Claudia Suenderhauf et al.

MOLECULES (2012)

Article Pharmacology & Pharmacy

Brain Pharmacokinetics of Two Prolyl Oligopeptidase Inhibitors, JTP-4819 and KYP-2047, in the Rat

Aaro J. Jalkanen et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2011)

Article Pharmacology & Pharmacy

Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner

T. T. Myohanen et al.

BRITISH JOURNAL OF PHARMACOLOGY (2011)

Article Neurosciences

Editorial [Hot Topic: Prolyl Oligopeptidase in Brain Function and Dysfunction (Guest Editor: J. Arturo Garcia-Horsman)]

J. Arturo Garcia-Horsman

CNS & Neurological Disorders-Drug Targets (2011)

Article Neurosciences

Role of Prolyl Endopeptidase in Intracellular Transport and Protein Secretion

M. Morawski et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2011)

Article Neurosciences

Prolyl Oligopeptidase, Inositol Phosphate Signalling and Lithium Sensitivity

Adrian J. Harwood

CNS & Neurological Disorders-Drug Targets (2011)

Article Neurosciences

Interaction of Prolyl Oligopeptidase with α-Synuclein

Anne-Marie Lambeir

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2011)

Article Neurosciences

Prolyl Oligopeptidase: A Rising Star on the Stage of Neuroinflammation Research

Anne Penttinen et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2011)

Article Neurosciences

Association of Prolyl Oligopeptidase with Conventional Neurotransmitters in the Brain

Iida Peltonen et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2011)

Review Clinical Neurology

Extracellular proteases in epilepsy

Katarzyna Lukasiuk et al.

EPILEPSY RESEARCH (2011)

Article Biochemistry & Molecular Biology

GAP43 shows partial co-localisation but no strong physical interaction with prolyl oligopeptidase

Zoltan Szeltner et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2010)

Article Medicine, Research & Experimental

Effects of Prolylendopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Experimental Depressive Syndrome Development in Rats

N. N. Khlebnikova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2009)

Article Medicine, Research & Experimental

Effect of a Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Alanyl-Proline on the Development of Experimental Depressive Syndrome in Rats

N. N. Khlebnikova et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2009)

Article Medicine, Research & Experimental

Behavioral Changes in Rats Induced by a Dipeptidyl Peptidase IV Inhibitor Methionyl-2(S)-Cyanopyrrolidine: Experimental Model of Anxiety-Depression Disorder

N. A. Krupina et al.

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2009)

Article Chemistry, Medicinal

Constrained Peptidomimetics Reveal Detailed Geometric Requirements of Covalent Prolyl Oligopeptidase Inhibitors

Janice Lawandi et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Neurosciences

Prolyl oligopeptidase binds to GAP-43 and functions without its peptidase activity

Elena Di Daniel et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2009)

Article Chemistry, Medicinal

Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)

Curt D. Haffner et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Article Cell Biology

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology

R. Liu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)

Article Pharmacology & Pharmacy

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats

Aaro J. Jalkanen et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2007)

Review Endocrinology & Metabolism

On the role of prolyl oligopeptidase in health and disease

J. A. Garcia-Horsman et al.

NEUROPEPTIDES (2007)

Article Pharmacology & Pharmacy

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors

JI Venäläinen et al.

BIOCHEMICAL PHARMACOLOGY (2006)

Article Biochemistry & Molecular Biology

Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion

I Schulz et al.

JOURNAL OF NEUROCHEMISTRY (2005)

Article Biochemistry & Molecular Biology

Substrate-dependent competency of the catalytic triad of prolyl oligopeptidase

Z Szeltner et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Effects of environmental enrichment on gene expression in the brain

C Rampon et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)