4.5 Review

Ten Years of Glory in the α-Functionalizations of Acetophenones: Progress Through Kornblum Oxidation and C-H Functionalization

Related references

Note: Only part of the references are listed.
Article Chemistry, Organic

Visible-Light-DrivenZ-Selective Reaction of Methyl Ketones with DMSO: A Mild Synthetic Approach to Methylthio-Substituted 1,4-Enedione Promoted by Selectfluor™

Gaurav K. Rastogi et al.

Summary: This method involves a simple, visible-light-driven Z-selective synthesis of methylthio-substituted 1,4-enedione in a single step promoted by Selectfluor. Dimethyl sulfoxide is used as both the 'thio' source and the solvent, with molecular iodine and potassium persulfate as catalyst and oxidant, and white light (CFL-30W) as the light source. The proposed mechanism includes a Kornblum reaction followed by aldol reaction.

SYNTHESIS-STUTTGART (2021)

Article Chemistry, Applied

Copper-catalyzed Reaction of Anthranils with Methyl Ketones: Site-Selective C5-Dicarbonylation of Anthranils

Shi-Yi Zhuang et al.

Summary: A novel synthetic method was developed using copper catalysis to achieve site-selective C5-dicarbonylation of anthranils, leading to the synthesis of 1,2-dicarbonyl compounds. This process represents the first example of implementing C5-dicarbonylation of anthranils, involving oxidative Csp(3)-H/Csp(2)-H cross-coupling reaction and thermolytic N-O bond cleavage.

ADVANCED SYNTHESIS & CATALYSIS (2021)

Article Chemistry, Multidisciplinary

One-Pot Synthesis of 1,5-Diketones under a Transition-Metal-Free Condition: Application in the Synthesis of 2,4,6-Triaryl Pyridine Derivatives

Kesatebrhan Haile Asressu et al.

Summary: A facile and green one-pot synthetic method was developed for substituted 1,3,5-triaryl-1,5-diketones with several advantages including a broad substrate scope, high yield, shorter reaction time, and environmentally friendly properties.

ACS OMEGA (2021)

Review Chemistry, Multidisciplinary

α-C-H functionalization of tertiary amines catalyzed/promoted by molecular iodine/derivatives

Mohit L. Deb et al.

Summary: This review article discusses the importance and effectiveness of functionalizing alpha-C-H bonds of tertiary amines via C-H activation catalyzed by iodine or its derivatives, as well as related organic transformations. This method is not only environmentally friendly, but also efficient in synthesizing a variety of nitrogen heterocycles and bioactive molecules.

NEW JOURNAL OF CHEMISTRY (2021)

Article Multidisciplinary Sciences

C-H activation

Torben Rogge et al.

Summary: C-H activation has emerged as a powerful platform for molecular syntheses in various fields including natural product syntheses, pharmaceutical industries, and material sciences. This Primer summarizes best practices for experimental set-up, data deposition, and key developments in C-H activation, as well as discussing its applications and limitations.

NATURE REVIEWS METHODS PRIMERS (2021)

Article Chemistry, Organic

Diastereoselective sp3-C-H Functionalization of Arylmethyl Ketones and Transformation of E- to Z-Products Through Photocatalysis

Gaurav K. Rastogi et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Recent advances in the application of acetophenone in heterocyclic compounds synthesis

Ghodsi Mohammadi Ziarani et al.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2020)

Review Chemistry, Multidisciplinary

Recent Advances on the C2-Functionalization of Indole via Umpolung

Bhaskar Deka et al.

TOPICS IN CURRENT CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

α-Functionalization of Ketones via a Nitrogen Directed Oxidative Umpolung

Gabriel M. Kiefl et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Organic

Palladium-Catalyzed Direct α-C(sp3) Heteroarylation of Ketones under Microwave Irradiation

Andrew Quillen et al.

JOURNAL OF ORGANIC CHEMISTRY (2019)

Review Chemistry, Multidisciplinary

3d Transition Metals for C-H Activation

Parthasarathy Gandeepan et al.

CHEMICAL REVIEWS (2019)

Review Chemistry, Organic

Recent advances in intramolecular C-O/C-N/C-S bond formation via C-H functionalization

Paran J. Borpatra et al.

ORGANIC CHEMISTRY FRONTIERS (2019)

Article Chemistry, Multidisciplinary

Oxidative Coupling of Naphthols to Ketones: An Approach to 1,2-Diketones

Mohit L. Deb et al.

CHEMISTRYSELECT (2018)

Article Biochemistry & Molecular Biology

Synthesis and Bioactivity Evaluation of Novel 2-Salicyloylbenzofurans as Antibacterial Agents

Phuong-Thuy T. Phan et al.

MOLECULES (2017)

Editorial Material Chemistry, Organic

Recent Advances in C-H Functionalization

Huw M. L. Davies et al.

JOURNAL OF ORGANIC CHEMISTRY (2016)

Article Chemistry, Organic

Copper-Catalyzed Asymmetric Oxidative Cross-Coupling of 2-Naphthols with Aryl Methyl Ketones

Tao Deng et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Organic

Copper(I)-Catalyzed Radical Addition of Acetophenones to Alkynes in Furan Synthesis

Srimanta Manna et al.

ORGANIC LETTERS (2015)

Review Chemistry, Organic

1,3-Diketones. Synthesis and properties

E. A. Shokova et al.

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (2015)

Article Chemistry, Multidisciplinary

Iodine-mediated oxidative annulation for one-pot synthesis of pyrazines and quinoxalines using a multipathway coupled domino strategy

K. K. Durga Rao Viswanadham et al.

CHEMICAL COMMUNICATIONS (2014)

Article Chemistry, Organic

Hypervalent Iodine-Promoted α-Fluorination of Acetophenone Derivatives with a Triethylamine•HF Complex

Tsugio Kitamura et al.

JOURNAL OF ORGANIC CHEMISTRY (2014)

Article Chemistry, Organic

The Redox-Mannich Reaction

Weijie Chen et al.

ORGANIC LETTERS (2014)

Article Chemistry, Organic

I2-DMSO catalyzed synthesis of 1,2,2-triarylethanones via dual C-H activation of aryl methyl ketones

M. Raghavender Reddy et al.

TETRAHEDRON LETTERS (2014)

Article Chemistry, Organic

Umpolung reactions at the α-carbon position of carbonyl compounds

Okiko Miyata et al.

ARKIVOC (2013)

Article Chemistry, Physical

In situ DRIFTS study on the catalytic oxidation of toluene over V2O5/TiO2 under mild conditions

Yunbing He et al.

CATALYSIS COMMUNICATIONS (2011)

Review Chemistry, Multidisciplinary

Self-Sorting Phenomena in Complex Supramolecular Systems

Marina M. Safont-Sempere et al.

CHEMICAL REVIEWS (2011)

Article Chemistry, Organic

Self-Sorting under Solvent-Free Conditions: One-Pot Synthesis of a Hetero[3]rotaxane

Pei-Nung Chen et al.

ORGANIC LETTERS (2011)

Article Chemistry, Multidisciplinary

Boron- and Fluorine-Containing Mesoporous Carbon Nitride Polymers: Metal-Free Catalysts for Cyclohexane Oxidation

Yong Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Review Chemistry, Multidisciplinary

Cross-Dehydrogenative Coupling (CDC): Exploring C-C Bond Formations beyond Functional Group Transformations

Chao-Jun Li

ACCOUNTS OF CHEMICAL RESEARCH (2009)

Article Chemistry, Multidisciplinary

Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds

James D. Sunderhaus et al.

CHEMISTRY-A EUROPEAN JOURNAL (2009)

Review Engineering, Chemical

Engineering aspects of industrial liquid-phase air oxidation of hydrocarbons

AK Suresh et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2000)