Journal
MATERIALS & DESIGN
Volume 210, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2021.110047
Keywords
Periodontal defect; GBR; Electrospinning membranes; 3D printed scaffolds; Hybrid bi-layer scaffold
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Funding
- National Key Research and Development Program of China [2016YFA0201703, 2016YFA0201700]
- Key Science and Technology Special Project of Sichuan Province [2020ZDZX0008]
- Chengdu Technology Innovation Research and Development Project
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The study demonstrates that a novel hybrid bi-layer scaffold fabricated using electrospun PCL/Gel nanofibre membranes combined with 3D printed PCL/Gel/n-HA scaffolds can promote bone regeneration effectively, showing good biocompatibility and bone growth potential.
The guided bone regeneration (GBR) concept has been extensively utilized to treat periodontal defects in clinical practice. However, the repair efficacy of the currently available GBR membranes is often compromised by their limited alveolar bone regeneration potential, insufficient mechanical strength and inadequate space maintenance duration. In this paper, a novel hybrid bi-layer scaffold was fabricated using electrospun polycaprolactone/gelatine (PCL/Gel) nanofibre membranes combined with 3D printed PCL/ Gel/nano-hydroxyapatite (n-HA) scaffolds. Their manipulation parameters and microstructures were investigated, and biological studies of in vitro and in vivo bone regeneration were carried out. The heparin-conjugated PCL/Gel fibrous membrane could significantly promote L929 fibroblast adhesion and proliferation. The PCL/Gel/n-HA (PGH) scaffold could promote attachment, growth and osteogenic differentiation of BMSCs. After 20 weeks, the defect sites in the hybrid bi-layer scaffold group showed a higher degree of new bone formation than that in the control group, indicating that this is a promising material combination for GBR. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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