Journal
PROBIOTICS AND ANTIMICROBIAL PROTEINS
Volume 14, Issue 6, Pages 1094-1109Publisher
SPRINGER
DOI: 10.1007/s12602-021-09870-9
Keywords
Probiotics; Antimutagenic agents; Antioxidants; Bacteria; Bbifidobacterium; Lactobacillus; Bacillus
Categories
Funding
- Ministry of Science and Higher Education of the Russian Federation [0852-2020-0029]
- Government of the Russian Federation [075-15-2019-1880]
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This study systematically compiles data on the antimutagenic activity of probiotics and emphasizes the significance of antimutagenic activity as a criterion for selecting probiotic strains.
The antimutagenic activity of probiotic strains has been reported over several decades of studying the effects of probiotics. However, this activity is rarely considered an important criterion when choosing strains to produce probiotic preparations and functional food. Meanwhile, the association of antimutagenic activity with the prevention of oncological diseases, as well as with a decrease in the spread of resistant forms in the microbiota, indicates its importance for the selection of probiotics. Besides, an antimutagenic activity can be associated with probiotics' broader systemic effects, such as geroprotective activity. The main mechanisms of such effects are considered to be the binding of mutagens, the transformation of mutagens, and inhibition of the transformation of promutagens into antimutagens. Besides, we should consider the possibility of interaction of the microbiota with regulatory processes in eukaryotic cells, in particular, through the effect on mitochondria. This work aims to systematize data on the antimutagenic activity of probiotics and emphasize antimutagenic activity as a significant criterion for the selection of probiotic strains.
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