Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 9, Issue 2, Pages 342-346Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo01633d
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- King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research [URF/1/4384]
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This study presents a novel method for deoxygenated fluorination of readily available carboxylic acids, resulting in the synthesis of a series of acyl fluorides. Scale-up reactions and sequential cross-couplings successfully demonstrated the feasibility and practicality of this fluorination protocol.
Herein we report the deoxygenated fluorination of readily available carboxylic acids. A series of acyl fluorides have been synthesized using shelf-stable N-trifluoromethylthiophthalimide as a fluorinated reagent for the first time. Scale-up reactions and sequential cross-couplings were performed successfully to demonstrate the practicability of this fluorination protocol.
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