4.7 Article

Mechanistic insights into the rhodium-catalyzed aryl C-H carboxylation

Journal

ORGANIC CHEMISTRY FRONTIERS
Volume 9, Issue 2, Pages 370-379

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qo01560e

Keywords

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Funding

  1. National Natural Science Foundation of China [51961135104, 21732006, 51821006]
  2. National Key R&D Program of China [2017YFA0303502]

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The study reveals the mechanism of Rh(II)-catalyzed lactonization reaction through density functional theory calculations, involving coordination exchange, C-H bond activation, carboxylation, protonation, and lactonization steps. The key steps are carboxylation and protonation, with the pKa value of the base predicting the energy barrier of the reaction.
The recently reported Rh(ii)-catalyzed direct C-H bond activation and lactonization of 2-arylphenols uncovers an attractive strategy to prepare coumarin derivatives with novel chemoselectivity. Motivated by the mechanistic ambiguity (on the origin of the chemoselectivity and the details for lactonization etc.), we conducted a detailed mechanistic study for the rhodium-catalyzed lactonization of 2-arylphenols with density functional theory (DFT) calculations. The results suggest that the reaction occurs via the coordination exchange, C-H bond activation, carboxylation, protonation and lactonization steps. The rate-determining step is the carboxylation, in which CO2 favorably inserts into the Rh-C bond (instead of the more nucleophilic Rh-O bond). The protonation step after carboxylation is critical, which makes the subsequent CO2-assisted lactonization feasible. Interestingly, the corresponding pK(a) value of the base can reasonably predict the reaction energy barrier of the C-H bond activation step. The calculations will provide insights and suggestions for developing and advancing the subsequent C-H bond activation carboxylation reaction.

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