Rh-Catalyzed diastereoselective addition of arylboronic acids to α-keto N-tert-butanesulfinyl aldimines: synthesis of α-amino ketones

Herein we present a diastereoselective addition of arylboronic acids to alpha-keto N-tert-butanesulfinyl aldimines catalyzed by a Rh(i) catalyst. This reaction provides a practical method to obtain valuable chiral alpha-amino ketones with excellent diastereoselectivity, featuring operational simplicity, mild reaction conditions and a broad substrate scope.

Automated summary

This paper presents a diastereoselective addition of arylboronic acids to alpha-keto N-tert-butanesulfinyl aldimines catalyzed by a Rh(i) catalyst, offering a practical method to obtain valuable chiral alpha-amino ketones with excellent diastereoselectivity. The reaction is characterized by operational simplicity, mild reaction conditions, and a broad substrate scope.