Journal
INTERNATIONAL JOURNAL OF DATA MINING AND BIOINFORMATICS
Volume 15, Issue 3, Pages 272-290Publisher
INDERSCIENCE ENTERPRISES LTD
DOI: 10.1504/IJDMB.2016.077073
Keywords
protein-protein interaction; protein feature extraction; pseudo amino acid composition; support vector machines
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Protein-protein interactions hold very important roles in biological processes. Prediction of PPIs is important for understanding these processes. In this context, substantive representations of proteins are needed during the process of interaction prediction in order to achieve higher prediction accuracy. In this paper, a new feature representation method, based on the concept of Chou's pseudo amino acid composition, was introduced. It is composed of the weighted amino acid composition information and the correlation factors of the protein. Finally, an SVM classification model was constructed for predicting PPIs. Experimental results exhibit that our method precedes those previously published in the literature.
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