Isolation of SARS-CoV-2 B.1.1.28.2 (P2) variant and pathogenicity comparison with D614G variant in hamster model

Article Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Wilfredo F. Garcia-Beltran et al.

Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.

CELL (2021)

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Article Multidisciplinary Sciences

Immunogenicity and protective efficacy of BBV152, whole virion inactivated SARS-CoV-2 vaccine candidates in the Syrian hamster model

Sreelekshmy Mohandas et al.

Summary: The study demonstrated that the BBV152A and BBV152B vaccine candidates induced quick and robust immune responses, providing protection to Syrian hamsters from lung pathology after SARS-CoV-2 infection.

ISCIENCE (2021)

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Article Multidisciplinary Sciences

Subtle differences in the pathogenicity of SARS-CoV-2 variants of concern B.1.1.7 and B.1.351 in rhesus macaques

Vincent J. Munster et al.

Summary: The study suggests that circulation under diverse evolutionary pressures favors transmissibility and immune evasion rather than increased pathogenicity.

SCIENCE ADVANCES (2021)

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Editorial Material Public, Environmental & Occupational Health

Neutralization of VUI B.1.1.28 P2 variant with sera of COVID-19 recovered cases and recipients of Covaxin an inactivated COVID-19 vaccine

Gajanan Sapkal et al.

JOURNAL OF TRAVEL MEDICINE (2021)

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Article Multidisciplinary Sciences

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Nuno R. Faria et al.

Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.

SCIENCE (2021)

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Review Biology

Biochemical role of serum ferratin and d-dimer parameters in COVID 19 diagnosis

Abdullah Farasani

Summary: COVID-19, the most unforgettable pandemic of the 21st century, was diagnosed and treated using key tests like serum ferritin and D-dimer levels.

SAUDI JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Medicine, General & Internal

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

Rana Abdelnabi et al.

Summary: The global COVID-19 pandemic has resulted in over 108 million infections and 2.4 million deaths within a year, with new variants of concern emerging. Research on prototypic VoC from B.1.1.7 and B.1.351 variants in hamsters revealed efficient infection of the lower respiratory tract and highlighted the need for assessing vaccine and therapeutic efficacy against these variants.

EBIOMEDICINE (2021)

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Article Microbiology

SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India

Sarah Cherian et al.

Summary: Genomic epidemiology and whole genome sequencing were used to investigate the transmission and evolution of the SARS-CoV-2 virus during the global pandemic. The study identified new variants B.1.617.1 and B.1.617.2 in India, responsible for the second wave of COVID-19 in Maharashtra, with B.1.617.2 designated as a VOC delta and B.1.617.1 as a variant of interest kappa. Monitoring of these and emerging variants in India is crucial for public health.

MICROORGANISMS (2021)

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Letter Immunology

Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil

Carolina Kymie Vasques Nonaka et al.

Summary: The case of reinfection from distinct virus lineages in Brazil with the E484K mutation raises concerns about the duration of protective immune responses against SARS-CoV-2, especially with the variant associated with escape from neutralizing antibodies. This highlights potential challenges for virus control measures.

EMERGING INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences