Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
Volume 10, Issue 2, Pages 550-555Publisher
ELSEVIER
DOI: 10.1016/j.jaip.2021.10.043
Keywords
Adverse drug reaction; Allergy; Ampicillin; Cepha-lexin; Cefaclor; Electronic heath record; Hypersensitivity; Intolerance; Penicillin; Sulfonamide antibiotic
Categories
Funding
- Kaiser Permanente Health Care Program
- Center for Effectiveness and Safety Research
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This study aimed to investigate the association between the use of b-lactams sharing exact R1 side chains and allergic reactions. The research tracked all courses of ACC and trimethoprimsulfamethoxazole used by Kaiser Permanente California members in 2017 and 2018, comparing with sulfonamide antibiotic allergy.
BACKGROUND: There is a theoretical concern, unconfirmed by population-based challenge data, that clinically significant, immunologically mediated hypersensitivity occurs among b-lactams sharing side chains. OBJECTIVE: To determine the population-based allergy incidence associated with the use of b-lactams sharing exact R1 side chains (ampicillin, cephalexin, and cefaclor [ACC]), with or without a current ACC allergy or a sulfonamide antibiotic allergy for comparison. METHODS: All courses of ACC and trimethoprimsulfamethoxazole used by any Kaiser Permanente California members in 2017 and 2018, with follow-up through January
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