4.5 Article

Controversies in Allergy: Choosing a Biologic for Patients with Severe Asthma

Related references

Note: Only part of the references are listed.
Article Allergy

EAACI Biologicals Guidelines-Omalizumab for the treatment of chronic spontaneous urticaria in adults and in the paediatric population 12-17 years old

Ioana Agache et al.

Summary: Chronic spontaneous urticaria (CSU) poses a significant burden on patients, families and healthcare systems, but a stratified approach to management supported by better understanding of mechanisms allows for targeted treatment with omalizumab.

ALLERGY (2022)

Review Allergy

Clinical Development of Mepolizumab for the Treatment of Severe Eosinophilic Asthma: On the Path to Personalized Medicine

Ian D. Pavord et al.

Summary: The development of mepolizumab, an anti-IL-5 monoclonal antibody, for the treatment of severe eosinophilic asthma exemplifies how clinical programs can evolve over time based on scientific principles. Initially disappointing results led to a shift in focus towards more severe patients, leading to clinically meaningful benefits in a targeted population identified through biomarker research. This personalized approach ultimately resulted in new and effective treatments for severe asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Review Immunology

Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies

Elizabeth A. Jacobsen et al.

Summary: Research on manipulating mouse and human eosinophils through experimental systems has made significant progress in revealing their roles in the immune system. Anti-eosinophil therapeutics have emerged as a new class of drugs, offering valuable insights into the consequences of eosinophil knockout in humans.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 (2021)

Article Allergy

What is the contribution of IgE to nasal polyposis?

Christina D. Chambers et al.

Summary: Nasal polyposis is characterized by high levels of functional polyclonal IgE, derived from various B-cell clones, which can induce and mediate the release of inflammatory mediators.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Critical Care Medicine

Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial

Joseph K. Han et al.

Summary: The study aimed to evaluate the efficacy and safety of mepolizumab in adults with recurrent, refractory severe bilateral chronic rhinosinusitis with nasal polyps. Results showed that mepolizumab treatment significantly improved nasal polyp size and nasal obstruction symptoms, with fewer adverse events.

LANCET RESPIRATORY MEDICINE (2021)

Letter Critical Care Medicine

Fractional Exhaled Nitric Oxide Nonsuppression Identifies Corticosteroid-Resistant Type 2 Signaling in Severe Asthma

Simon Couillard et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Review Critical Care Medicine

Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management

Eugene R. Bleecker et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Letter Critical Care Medicine

The Use of Benralizumab in the Treatment of Near-Fatal Asthma: A New Approach

Sanjay Ramakrishnan et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Letter Critical Care Medicine

Blood Eosinophil Depletion with Mepolizumab, Benralizumab, and Prednisolone in Eosinophilic Asthma

Angela M. Moran et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Article Allergy

Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials

Philippe Gevaert et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Allergy

Anti-IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison

William Busse et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Letter Critical Care Medicine

Prognostic and Predictive Value of Blood Eosinophil Count, Fractional Exhaled Nitric Oxide, and Their Combination in Severe Asthma: A Post Hoc Analysis

Rahul Shrimanker et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

Article Medicine, General & Internal

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

Klaus F. Rabe et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

M. Castro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis

M. E. Wechsler et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma

Parameswaran Nair et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Pharmacology & Pharmacy

Reslizumab in patients with inadequately controlled late-onset asthma and elevated blood eosinophils

Guy Brusselle et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2017)

Article Cardiac & Cardiovascular Systems

Comparative effectiveness of mepolizumab and omalizumab in severe asthma: An indirect treatment comparison

Sarah M. Cockle et al.

RESPIRATORY MEDICINE (2017)

Article Medicine, General & Internal

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis A Randomized Clinical Trial

Claus Bachert et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Medicine, General & Internal

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

Lisa A. Beck et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

Elisabeth H. Bel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

Hector G. Ortega et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Allergy

Omalizumab in Asthma: An Update on Recent Developments

Marc Humbert et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2014)

Article Critical Care Medicine

Exploring the Effects of Omalizumab in Allergic Asthma An Analysis of Biomarkers in the EXTRA Study

Nicola A. Hanania et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Medicine, General & Internal

Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy A Randomized Trial

Nicola A. Hanania et al.

ANNALS OF INTERNAL MEDICINE (2011)

Article Medicine, General & Internal

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

William W. Busse et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Letter Respiratory System

Mepolizumab in refractory eosinophilic asthma

I. D. Pavord et al.

THORAX (2010)

Article Medicine, General & Internal

Treatment of patients with the hypereosinophilic syndrome with mepolizumab

Marc E. Rothenberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)