Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.769442
Keywords
COVID-19; T-cell receptor; asymptomatic patient; re-detectable positive case; immune repertoire sequencing
Categories
Funding
- Science and Technology Innovation Project of Foshan Municipality [2020001000431]
- National Key~Research and Development Project [2020YFA0708001]
- Guangdong Provincial Science and Technology Project [2020A1414010363]
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By analyzing the peripheral T-cell receptor repertoire of 54 COVID-19 patients, a set of characteristic gene combinations were identified to distinguish asymptomatic and symptomatic patients, and predict the risk of recurrence in re-detectable positive cases. These findings have the potential to strengthen clinical surveillance and the development of immunotherapy for COVID-19.
The prevention of the COVID-19 pandemic is highly complicated by the prevalence of asymptomatic and recurrent infection. Many previous immunological studies have focused on symptomatic and convalescent patients, while the immune responses in asymptomatic patients and re-detectable positive cases remain unclear. Here we comprehensively analyzed the peripheral T-cell receptor (TCR) repertoire of 54 COVID-19 patients in different courses, including asymptomatic, symptomatic, convalescent, and re-detectable positive cases. We identified a set of V-J gene combinations characterizing the upward immune responses through asymptomatic and symptomatic courses. Furthermore, some of these V-J combinations could be awakened in the re-detectable positive cases, which may help predict the risk of recurrent infection. Therefore, TCR repertoire examination has the potential to strengthen the clinical surveillance and the immunotherapy development for COVID-19.
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