Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.729607
Keywords
germinal center; Peyer's patches; gamma delta T cells; V gamma 1(+) T cells; IL-4; IgA
Categories
Funding
- Medical School of Hannover (HILF I-Hochschul interne Leistungs foerderung [79228008]
- Forschung sgemein schaft [PR727/8-1, PR727/13-1]
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The study found that gamma delta T cells play an important role in the GC reactions in the Peyer's patches of the small intestine, driving the proliferation of GC B cells and the switch towards IgA by producing IL-4, thus maintaining gut homeostasis and symbiosis.
The mucosal immune system is the first line of defense against pathogens. Germinal centers (GCs) in the Peyer's patches (PPs) of the small intestine are constantly generated through stimulation of the microbiota. In this study, we investigated the role of gamma delta T cells in the GC reactions in PPs. Most gamma delta T cells in PPs localized in the GCs and expressed a TCR composed of V gamma 1 and V delta 6 chains. By using mice with partial and total gamma delta T cell deficiencies, we found that V gamma 1(+)/V delta 6(+) T cells can produce high amounts of IL-4, which drives the proliferation of GC B cells as well as the switch of GC B cells towards IgA. Therefore, we conclude that gamma delta T cells play a role in sustaining gut homeostasis and symbiosis via supporting the GC reactions in PPs.
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