Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.742167
Keywords
spike protein; SARS-CoV-2; secondary infection; breakthrough infection; vaccine; COVID-19; variants; immune evasion
Categories
Ask authors/readers for more resources
This article discusses the pressures leading to the emergence of new SARS-CoV-2 variants and key mutations that promote immune escape mechanisms, highlighting the potential threats to the efficacy of current COVID-19 vaccines. It cautions on the risks of reinfection, vaccine breakthrough infections, and therapeutic values.
COVID-19 pandemic remains an on-going global health and economic threat that has amassed millions of deaths. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of this disease and is constantly under evolutionary pressures that drive the modification of its genome which may represent a threat to the efficacy of current COVID-19 vaccines available. This article highlights the pressures that facilitate the rise of new SARS-CoV-2 variants and the key mutations of the viral spike protein - L452R, E484K, N501Y and D614G- that promote immune escape mechanism and warrant a cautionary point for clinical and public health responses in terms of re-infection, vaccine breakthrough infection and therapeutic values.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available