Related references
Note: Only part of the references are listed.Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease
Sahabuddin Ahmed et al.
BRAIN BEHAVIOR AND IMMUNITY (2021)
Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases
An-Guo Wu et al.
AGEING RESEARCH REVIEWS (2021)
α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia
Adrianne F. Pike et al.
GLIA (2021)
PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats
Majken B. Thomsen et al.
NEUROBIOLOGY OF DISEASE (2021)
Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
Dorit Trudler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
NLRP3 Inflammasome Inhibition Prevents α-Synuclein Pathology by Relieving Autophagy Dysfunction in Chronic MPTP-Treated NLRP3 Knockout Mice
Zhou Ou et al.
MOLECULAR NEUROBIOLOGY (2021)
Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease
Md Ezazul Haque et al.
MOVEMENT DISORDERS (2020)
Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease
Zheng Fan et al.
JOURNAL OF NEUROINFLAMMATION (2020)
Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway
Jae-Hyeon Park et al.
MOLECULAR NEURODEGENERATION (2020)
Characterization of novel conformation-selective alpha-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease
Michael X. Henderson et al.
NEUROBIOLOGY OF DISEASE (2020)
Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts
Margaux Teil et al.
BIOMOLECULES (2020)
Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
Marta Gallardo-Fernandez et al.
ANTIOXIDANTS (2020)
Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease
Min Guo et al.
BRAIN (2020)
[18F]-DPA-714 PET as a specific in vivo marker of early microglial activation in a rat model of progressive dopaminergic degeneration
Tatiana Rodriguez-Chinchilla et al.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2020)
Microglia clear neuron-released a-synuclein via selective autophagy and prevent neurodegeneration
Insup Choi et al.
NATURE COMMUNICATIONS (2020)
IL-1β/IL-1R1 signaling induced by intranasal lipopolysaccharide infusion regulates alpha-synuclein pathology in the olfactory bulb, substantia nigra and striatum
Haichen Niu et al.
BRAIN PATHOLOGY (2020)
Inflammation in Parkinson's Disease: Mechanisms and Therapeutic Implications
Marta Pajares et al.
CELLS (2020)
Naphthoquinone-Dopamine Hybrids Inhibit α-Synuclein Aggregation, Disrupt Preformed Fibrils, and Attenuate Aggregate-Induced Toxicity
Ashim Paul et al.
CHEMISTRY-A EUROPEAN JOURNAL (2020)
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease
Nora Bengoa-Vergniory et al.
NATURE COMMUNICATIONS (2020)
Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance
Miguel Lemos et al.
TRANSLATIONAL NEURODEGENERATION (2020)
CMT-3 targets different α-synuclein aggregates mitigating their toxic and inflammogenic effects
Florencia L. Gonzalez-Lizarraga et al.
SCIENTIFIC REPORTS (2020)
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Hyuk Sung Kwon et al.
TRANSLATIONAL NEURODEGENERATION (2020)
MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration
Eunju Lee et al.
CELL DEATH AND DIFFERENTIATION (2019)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis
Craig D. Hughes et al.
ACTA NEUROPATHOLOGICA (2019)
The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease
Shuo Wang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2019)
Kaempferol Attenuates LPS-Induced Striatum Injury in Mice Involving Anti-Neuroinflammation, Maintaining BBB Integrity, and Down-Regulating the HMGB1/TLR4 Pathway
Ying-Lin Yang et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Farrerol attenuates MPP+-induced inflammatory response by TLR4 signaling in a microglia cell line
Bei Cui et al.
PHYTOTHERAPY RESEARCH (2019)
Microglia as modulators of exosomal alpha-synuclein transmission
Yun Xia et al.
CELL DEATH & DISEASE (2019)
Multikinase Abl/DDR/Src Inhibition Produces Optimal Effects for Tyrosine Kinase Inhibition in Neurodegeneration
Alan J. Fowler et al.
DRUGS IN R&D (2019)
Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models
Hayate Javed et al.
FRONTIERS IN PHARMACOLOGY (2019)
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease
Xiaojuan Han et al.
AUTOPHAGY (2019)
Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson's disease
C. Warren Olanow et al.
BRAIN (2019)
Targeting -Synuclein in Parkinson's Disease: Progress Towards the Development of Disease-Modifying Therapeutics
Daniel Savitt et al.
DRUGS (2019)
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
Nikhil Panicker et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation
Shu Yao et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2019)
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
Andreas Weihofen et al.
NEUROBIOLOGY OF DISEASE (2019)
Triptolide Inhibits Preformed Fibril-Induced Microglial Activation by Targeting the MicroRNA155-5p/SHIP1 Pathway
Yang Feng et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)
Microglia-mediated neuroinflammation in neurodegenerative diseases
Charannya Sozheesvari Subhramanyam et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2019)
Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model
Liyan Hou et al.
REDOX BIOLOGY (2019)
Increased Immune Activation by Pathologic α-Synuclein in Parkinson's Disease
Veselin Grozdanov et al.
ANNALS OF NEUROLOGY (2019)
The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy
Marcos Herrera-Vaquero et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)
Progress of immunotherapy of anti-α-synuclein in Parkinson's disease
Zhipeng Wang et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies
Antonina Kouli et al.
BRAIN BEHAVIOR AND IMMUNITY (2019)
Exosomes from patients with Parkinson's disease are pathological in mice
Chao Han et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2019)
Randomized phase I clinical trial of anti-α-synuclein antibody BIIB054
Miroslaw Brys et al.
MOVEMENT DISORDERS (2019)
Mitochondrial damage by α-synuclein causes cell death in human dopaminergic neurons
Goutham K. Ganjam et al.
CELL DEATH & DISEASE (2019)
TLR4 absence reduces neuroinflammation and inflammasome activation in Parkinson's diseases in vivo model
Michela Campolo et al.
BRAIN BEHAVIOR AND IMMUNITY (2019)
Peripheral Immunity, Immunoaging and Neuroinflammation in Parkinson's Disease
Natasa Kustrimovic et al.
CURRENT MEDICINAL CHEMISTRY (2019)
The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS
Ravinder Malik et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegeneration
Alevtina Zharikov et al.
NEUROBIOLOGY OF DISEASE (2019)
Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study
Koustav Chatterjee et al.
JOURNAL OF NEUROIMMUNOLOGY (2019)
Calycosin attenuates MPTP-induced Parkinson's disease by suppressing the activation of TLR/NF-κB and MAPK pathways
Jing Yang et al.
PHYTOTHERAPY RESEARCH (2019)
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo
Darren J. Schofield et al.
NEUROBIOLOGY OF DISEASE (2019)
Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology
Xinyi Li et al.
ACTA NEUROPATHOLOGICA (2019)
Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration
S. N. Suresh et al.
EBIOMEDICINE (2019)
Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson's disease with dementia
Deepthi Yedlapudi et al.
SCIENTIFIC REPORTS (2019)
Chaperone-mediated autophagy and endosomal microautophagy: Jointed by a chaperone
Kumsal Tekirdag et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
MicroRNA-30e regulates neuroinflammation in MPTP model of Parkinson's disease by targeting Nlrp3
Dongsheng Li et al.
HUMAN CELL (2018)
Juglanin ameliorates LPS-induced neuroinflammation in animal models of Parkinson's disease and cell culture via inactivating TLR4/NF-κB pathway
Fang-Xue Zhang et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease
Yi-Ying Huang et al.
BRAIN BEHAVIOR AND IMMUNITY (2018)
Release and uptake of pathologic alpha-synuclein
Veselin Grozdanov et al.
CELL AND TISSUE RESEARCH (2018)
C-Abl Inhibition; A Novel Therapeutic Target for Parkinson's Disease
Abdelrahman Ibrahim Abushouk et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2018)
Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease
Ashley S. Harms et al.
EXPERIMENTAL NEUROLOGY (2018)
Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop
Francois Mouton-Liger et al.
GLIA (2018)
Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis
Guangrui Huang et al.
MOLECULAR IMMUNOLOGY (2018)
Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization
Yuning Che et al.
CELL DEATH & DISEASE (2018)
Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti-a-Synuclein Monoclonal Antibody, in Patients With Parkinson Disease A Randomized Clinical Trial
Joseph Jankovic et al.
JAMA NEUROLOGY (2018)
Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway
Liyan Hou et al.
REDOX BIOLOGY (2018)
Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation
Changyoun Kim et al.
MOLECULAR NEURODEGENERATION (2018)
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
Zhenyu Zhong et al.
NATURE (2018)
Microglia in neurodegeneration
Suzanne Hickman et al.
NATURE NEUROSCIENCE (2018)
Inflammasome signalling in brain function and neurodegenerative disease
Michael T. Heneka et al.
NATURE REVIEWS NEUROSCIENCE (2018)
miR-146a Attenuates Sepsis-Induced Myocardial Dysfunction by Suppressing IRAK1 and TRAF6 via Targeting ErbB4 Expression
Rui An et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease
Diana L. Price et al.
SCIENTIFIC REPORTS (2018)
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
Richard Gordon et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Toll-like receptor 2 is increased in neurons in Parkinson's disease brain and may contribute to alpha-synuclein pathology
Nicolas Dzamko et al.
ACTA NEUROPATHOLOGICA (2017)
Triptolide Promotes the Clearance of α-Synuclein by Enhancing Autophagy in Neuronal Cells
Guanzheng Hu et al.
MOLECULAR NEUROBIOLOGY (2017)
FLZ Attenuates α-Synuclein-Induced Neurotoxicity by Activating Heat Shock Protein 70
Xiu-Qi Bao et al.
MOLECULAR NEUROBIOLOGY (2017)
First-in-human assessment of PRX002, an anti--synuclein monoclonal antibody, in healthy volunteers
Dale B. Schenk et al.
MOVEMENT DISORDERS (2017)
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
Si Ming Man et al.
IMMUNOLOGICAL REVIEWS (2017)
The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface
David Bier et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01
Tobias Voepel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein
Franziska Richter et al.
NEUROTHERAPEUTICS (2017)
Paraquat and maneb co-exposure induces noradrenergic locus coeruleus neurodegeneration through NADPH oxidase-mediated microglial activation
Liyan Hou et al.
TOXICOLOGY (2017)
c-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential
Saurav Brahmachari et al.
JOURNAL OF PARKINSONS DISEASE (2017)
Parkinson disease
Werner Poewe et al.
NATURE REVIEWS DISEASE PRIMERS (2017)
α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration
Ashley S. Harms et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2017)
Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway
Haoran Jing et al.
PLOS ONE (2017)
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease
Souvarish Sarkar et al.
NPJ PARKINSONS DISEASE (2017)
Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production
Victor Tapias et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome
Inna S. Afonina et al.
NATURE IMMUNOLOGY (2017)
Reduced plasma taurine level in Parkinson's disease: association with motor severity and levodopa treatment
Li Zhang et al.
INTERNATIONAL JOURNAL OF NEUROSCIENCE (2016)
Alpha-synuclein activates BV2 microglia dependent on its aggregation state
Alana Hoffmann et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease
Wolfgang Wrasidlo et al.
BRAIN (2016)
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
Zhenyu Zhong et al.
CELL (2016)
α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity
Zhaoyang Hu et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)
Pyroptosis
Lieselotte Vande Walle et al.
CURRENT BIOLOGY (2016)
Human Monocytes Engage an Alternative Inflammasome Pathway
Moritz M. Gaidt et al.
IMMUNITY (2016)
MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease
Yan Zhou et al.
MOLECULAR NEURODEGENERATION (2016)
Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies
Maria Xilouri et al.
MOVEMENT DISORDERS (2016)
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease
Roberto Di Maio et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease
Lars Tatenhorst et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)
Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2
Changyoun Kim et al.
EXPERIMENTAL NEUROBIOLOGY (2016)
Salusin-β induces foam cell formation and monocyte adhesion in human vascular smooth muscle cells via miR155/NOX2/NFκB pathway
Hai-Jian Sun et al.
SCIENTIFIC REPORTS (2016)
Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes
Emmy H. Rannikko et al.
BMC NEUROSCIENCE (2015)
Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models
Qingshan Wang et al.
BRAIN (2015)
Fibril growth and seeding capacity play key roles in α-synuclein-mediated apoptotic cell death
A-L Mahul-Mellier et al.
CELL DEATH AND DIFFERENTIATION (2015)
Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease
Elvira Valera et al.
JOURNAL OF NEUROINFLAMMATION (2015)
Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease
Changyoun Kim et al.
JOURNAL OF NEUROINFLAMMATION (2015)
Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations
Benjamin Dehay et al.
LANCET NEUROLOGY (2015)
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki et al.
NATURE (2015)
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi et al.
NATURE (2015)
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Serene W. Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
Stefano G. Daniele et al.
SCIENCE SIGNALING (2015)
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
Changyoun Kim et al.
CELL REPORTS (2015)
Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders
Stefano G. Daniele et al.
SCIENCE SIGNALING (2015)
Taurine and inflammatory diseases
Janusz Marcinkiewicz et al.
AMINO ACIDS (2014)
Taurine and central nervous system disorders
Janet Menzie et al.
AMINO ACIDS (2014)
Subpicomolar Diphenyleneiodonium Inhibits Microglial NADPH Oxidase with High Specificity and Shows Great Potential as a Therapeutic Agent for Neurodegenerative Diseases
Qingshan Wang et al.
GLIA (2014)
2-Cyclopropylimino-3-Methyl-1,3-Thiazoline Hydrochloride Inhibits Microglial Activation by Suppression of Nuclear Factor-Kappa B and Mitogen-Activated Protein Kinase Signaling
Eun-A Kim et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2014)
Neuroinflammation and α-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction
Edward I. Ginns et al.
MOLECULAR GENETICS AND METABOLISM (2014)
Inflammatory caspases are innate immune receptors for intracellular LPS
Jianjin Shi et al.
NATURE (2014)
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
Alberto Baroja-Mazo et al.
NATURE IMMUNOLOGY (2014)
Inflammasomes in the CNS
John G. Walsh et al.
NATURE REVIEWS NEUROSCIENCE (2014)
A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology
Petra Pasanen et al.
NEUROBIOLOGY OF AGING (2014)
G51D α-Synuclein mutation causes a novel Parkinsonian-pyramidal syndrome
Suzanne Lesage et al.
ANNALS OF NEUROLOGY (2013)
Regulation of the MIR155 host gene in physiological and pathological processes
Terry S. Elton et al.
GENE (2013)
Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease
Silke Appel-Cresswell et al.
MOVEMENT DISORDERS (2013)
The many faces of alpha-synuclein: from structure and toxicity to therapeutic target
Hilal A. Lashuel et al.
NATURE REVIEWS NEUROSCIENCE (2013)
A NOVEL α-SYNUCLEIN MISSENSE MUTATION IN PARKINSON DISEASE
Christos Proukakis et al.
NEUROLOGY (2013)
Microglia, Amyloid, and Glucose Metabolism in Parkinson's Disease with and without Dementia
Paul Edison et al.
NEUROPSYCHOPHARMACOLOGY (2013)
Triggering of Inflammasome by Aggregated α-Synuclein, an Inflammatory Response in Synucleinopathies
Gaia Codolo et al.
PLOS ONE (2013)
Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
Jon A. Hagar et al.
SCIENCE (2013)
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
Changyoun Kim et al.
NATURE COMMUNICATIONS (2013)
The Role of Oxidative Stress in Parkinson's Disease
Vera Dias et al.
JOURNAL OF PARKINSONS DISEASE (2013)
Inflammasomes and Their Roles in Health and Disease
Mohamed Lamkanfi et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 28 (2012)
Fibrillar α-Synuclein and Huntingtin Exon 1 Assemblies Are Toxic to the Cells
Laura Pieri et al.
BIOPHYSICAL JOURNAL (2012)
Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers
Aida Attar et al.
BRAIN (2012)
Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia
Ke-Wu Zeng et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2012)
Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein
Melanie B. Watson et al.
EXPERIMENTAL NEUROLOGY (2012)
Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson's disease
Weilin Xie et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Inflammasomes in health and disease
Till Strowig et al.
NATURE (2012)
A Novel Molecular Tweezer Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo
Shubhangi Prabhudesai et al.
NEUROTHERAPEUTICS (2012)
Triptolide Down-regulates COX-2 Expression and PGE2 Release by Suppressing the Activity of NF-?B and MAP kinases in Lipopolysaccharide-treated PC12 Cells
Yu Geng et al.
PHYTOTHERAPY RESEARCH (2012)
NADPH oxidases: novel therapeutic targets for neurodegenerative diseases
Hui-Ming Gao et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2012)
Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons
Nadia Stefanova et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Glia: Initiators and Progressors of Pathology in Parkinson's Disease
Glenda M. Halliday et al.
MOVEMENT DISORDERS (2011)
Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies
Karen Rees et al.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2011)
Anti-inflammatory drugs and risk of Parkinson disease A meta-analysis
Joshua J. Gagne et al.
NEUROLOGY (2010)
Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation
Luigi Franchi et al.
JOURNAL OF IMMUNOLOGY (2009)
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Franz G. Bauernfeind et al.
JOURNAL OF IMMUNOLOGY (2009)
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
Kelvin C. Luk et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Classical Inhibitors of NOX NAD(P) H Oxidases Are Not Specific
Elisabetta Aldieri et al.
CURRENT DRUG METABOLISM (2008)
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein
He-Jin Lee et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
Susan L. Fink et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Pyroptosis and host cell death responses during Salmonella infection
Susan L. Fink et al.
CELLULAR MICROBIOLOGY (2007)
DAMPs, PAMPs and alarmins: all we need to know about danger
Marco E. Bianchi
JOURNAL OF LEUKOCYTE BIOLOGY (2007)
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
Karen Bedard et al.
PHYSIOLOGICAL REVIEWS (2007)
Amino acid sequence motifs and mechanistic features of the membrane translocation of α-synuclein
KJ Ahn et al.
JOURNAL OF NEUROCHEMISTRY (2006)
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
JJ Zarranz et al.
ANNALS OF NEUROLOGY (2004)
α-synuclein locus duplication as a cause of familial Parkinson's disease
MC Chartier-Harlin et al.
LANCET (2004)
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
JK Olson et al.
JOURNAL OF IMMUNOLOGY (2004)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
Conformational properties of α-synuclein in its free and lipid-associated states
D Eliezer et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
A Abeliovich et al.
NEURON (2000)