4.8 Review

Immunostimulatory Properties of Chemotherapy in Breast Cancer: From Immunogenic Modulation Mechanisms to Clinical Practice

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Good cops turn bad: The contribution of neutrophils to immune-checkpoint inhibitor treatment failures in cancer

Huajia Zhang et al.

Summary: Immune checkpoint inhibitor therapy activates tumor-killing T-cells by releasing the brake of anti-tumor immunity, but a majority of patients are refractory to the therapy. Recent studies suggest that high neutrophil content is associated with poor response rates, indicating that neutrophil antagonism may improve the efficacy of immune checkpoint inhibitor therapy.

PHARMACOLOGY & THERAPEUTICS (2021)

Review Biochemistry & Molecular Biology

Progress and challenges of immunotherapy in triple-negative breast cancer

Yinxing Zhu et al.

Summary: The article discusses the relevance of TNBC and immunotherapy, summarizing the current progress in targeting different immune checkpoints in TNBC treatment and potential predictive biomarkers.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Article Oncology

HMGB1 is a key factor for tamoxifen resistance and has the potential to predict the efficacy of CDK4/6 inhibitors in breast cancer

Han Zhang et al.

Summary: In breast cancer patients, increased expression of HMGB1 is associated with endocrine resistance, and HMGB1-positive patients benefit more in PFS when receiving CDK4/6 inhibitors treatment. HMGB1 promotes tamoxifen resistance through the TLR4-NF-kappa B pathway.

CANCER SCIENCE (2021)

Review Immunology

Regulatory T cell targeting in cancer: Emerging strategies in immunotherapy

Sundee Dees et al.

Summary: Treg cells play a crucial role in maintaining immune homeostasis, and targeting them can enhance antitumor immunity, although the efficacy of current Treg therapies in clinical settings is limited due to lack of specificity. Novel approaches, such as T-cell receptor mimic antibodies and near-infrared photoimmunotherapy, aim to address this limitation in the context of cancer.

EUROPEAN JOURNAL OF IMMUNOLOGY (2021)

Article Cell Biology

HN1L promotes migration and invasion of breast cancer by up-regulating the expression of HMGB1

Dechuang Jiao et al.

Summary: Research has shown that HN1L gene is significantly over-expressed in breast cancer tissues and positively correlated with M metastasis in breast cancer patients. Silencing HN1L can effectively inhibit the invasion and metastasis of breast cancer cells. HN1L interacts with HSPA9 and affects the expression of HMGB1, playing a key role in promoting the invasion and metastasis of breast cancer cells. These findings suggest that HN1L may be a potential drug target for breast cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Oncology

The immunomodulatory effects of endocrine therapy in breast cancer

Huanhuan Huang et al.

Summary: SERMs and SERDs are standard therapies for ER-positive breast cancer, and they also modulate the immune microenvironment. The immune microenvironment plays a crucial role in tumor development, treatment response, and could potentially enhance the effectiveness of immune checkpoint inhibitors in breast cancer treatment.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Multidisciplinary Sciences

Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress

Zhusheng Huang et al.

Summary: The study demonstrates a strategy of using gadolinium-based nanoscale coordination polymers to enhance radiation-induced immunogenic cell death, thereby boosting anti-tumor immune responses.

NATURE COMMUNICATIONS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Immunology

STAT3 Silencing and TLR7/8 Pathway Activation Repolarize and Suppress Myeloid-Derived Suppressor Cells From Breast Cancer Patients

Elham Safarzadeh et al.

Summary: The study found that the levels of HLA-DR(-)CD33(+) MDSCs in the blood of breast cancer patients are elevated, and these cells can strongly suppress T cell proliferation and enter the tumor microenvironment. Inhibiting the STAT3 signaling pathway and activating the TLR7/8 pathway can reduce the immunosuppressive effects of patient-derived MDSCs on T cells and decrease breast cancer cell proliferation.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

Enhance the Immune Checkpoint Inhibitors Efficacy with Radiotherapy Induced Immunogenic Cell Death: A Comprehensive Review and Latest Developments

Adrien Procureur et al.

Summary: Efficient antitumoral immune response relies on immunogenic cell death, which can be induced by various factors including radiation therapy. The synergistic mechanisms between radiation therapy and immune checkpoint inhibitors are promising, but robust clinical evidence is still limited. Radioimmunology is a rapidly evolving field with numerous ongoing clinical trials.

CANCERS (2021)

Article Oncology

Complete rejection of large established breast cancer by local immunochemotherapy with T cell activation against neoantigens

Junxia Gao et al.

Summary: This study found that local immunochemotherapy can trigger powerful antitumor immune responses, successfully eliminating breast cancer tumors and inducing systemic T cell responses. This method provides a novel approach to target highly diverse neoantigens in different types of cancers.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Oncology

Eribulin Plus Pembrolizumab in Patients with Metastatic Triple-Negative Breast Cancer (ENHANCE 1): A Phase Ib/II Study

Sara M. Tolaney et al.

Summary: The study investigated the efficacy and safety of combination therapy with eribulin and pembrolizumab in mTNBC, showing promising antitumor activity in this population. Efficacy outcomes appeared to be influenced by the line of therapy and PD-L1 status.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells

Diwakar Bastihalli Tukaramrao et al.

Summary: This study reports a novel compound, TPH104, that induces a unique, non-apoptotic cell death in triple-negative breast cancer (TNBC) cells by activating dendritic cells (DCs). TPH104 enhances the tumor immunogenic microenvironment to increase the efficacy of conventional chemotherapy for TNBC.

CANCERS (2021)

Article Cell Biology

A Comprehensive Investigation to Reveal the Relationship Between Plasmacytoid Dendritic Cells and Breast Cancer by Multiomics Data Analysis

Saisai Tian et al.

Summary: This study found that elevated levels of plasmacytoid dendritic cells (pDC) were associated with prolonged survival outcomes in breast cancer patients, with lower mutation burden and intratumoral heterogeneity observed in the high pDC abundance group. Patients with high pDC abundance showed a more sensitive immune response and better chemotherapy outcomes, suggesting potential benefits from combination therapy.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Oncology

Primary results from IMpassion131, a double-blind, placebo-controlled, randomised phase III trial of first-line paclitaxel with or without atezolizumab for unresectable locally advanced/metastatic triple-negative breast cancer

D. Miles et al.

Summary: Combining atezolizumab with paclitaxel did not improve PFS or OS in PD-L1-positive aTNBC patients, although it showed some advantage in unconfirmed best overall response rate and duration of response.

ANNALS OF ONCOLOGY (2021)

Article Oncology

Immunogenomic profiling and pathological response results from a clinical trial of docetaxel and carboplatin in triple-negative breast cancer

Foluso O. Ademuyiwa et al.

Summary: Neoadjuvant docetaxel and carboplatin resulted in a pCR rate of 45.7% in TNBC patients. Whole-exome sequencing and immune profiling were able to differentiate patients with and without pCR.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Review Immunology

Breast cancer immunotherapy: Current and novel approaches

Khadijeh Barzaman et al.

Summary: The study emphasizes the crucial role of the immune system in breast cancer treatment, and discusses the importance of using various immunotherapy methods in conjunction with traditional chemotherapy to improve patient survival rates, while pointing out the obstacles that still need to be addressed.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Article Immunology

Autologous Dendritic Cells in Combination With Chemotherapy Restore Responsiveness of T Cells in Breast Cancer Patients: A Single-Arm Phase I/II Trial

David A. Bernal-Estevez et al.

Summary: This study investigates the safety and immunogenicity of autologous antigen-free DCs administered to breast cancer patients (BCPs) in combination with NAC-AC. The results suggest that the administration of DCs in combination with NAC-AC enhances the functional capacity of T cells in BCPs, potentially potentiating the adjuvant effect of ICD induced by NAC-AC on T cells and increasing the immunogenicity of tumors as cryptic vaccines.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies

Angela-Patricia Hernandez et al.

Summary: The concept of cancer as a single cell mass that replicates unlimitedly in isolation has been dissolved with the inclusion of immune evasion as a hallmark. Tumor microenvironment (TME) plays a crucial role in drug resistance, impacting the success of treatment. Immunogenic cell death (ICD) elicited by cancer therapy reshapes the tumor immune microenvironment, initiating a long-term adaptative immune response.

CANCERS (2021)

Review Oncology

Advancing to the era of cancer immunotherapy

Yun Wang et al.

Summary: Cancer has a significant impact on the quality of life of humans globally, with the number of patients continuously increasing. The focus of cancer research has shifted towards anti-tumor immunity and the booming development of immunotherapy, leading to a new era in cancer treatment.

CANCER COMMUNICATIONS (2021)

Article Oncology

Plasma cell infiltration and treatment effect in breast cancer patients treated with neoadjuvant chemotherapy

Asumi Sakaguchi et al.

Summary: This study found that higher levels of plasma cells (PCs) infiltration in biopsy specimens before neoadjuvant chemotherapy were associated with pathological complete response (pCR). Through multiplexed fluorescent immunohistochemistry (mfIHC), it was also revealed that the local cytotoxic immune response was enhanced in pCR cases, with increased infiltration of B cells including PCs. Furthermore, higher levels of PCs were correlated with favorable outcomes in hormone receptor-negative breast cancer patients.

BREAST CANCER RESEARCH (2021)

Review Cell Biology

Calreticulin and cancer

Jitka Fucikova et al.

Summary: CALR is a protein located in the endoplasmic reticulum that plays important roles in cellular processes and protein folding. It acts as a chaperone in healthy cells, assisting protein folding and supporting Ca2+-dependent processes, while also being exposed on the cell surface in cancer cells to promote immunogenic cell death. Loss-of-functionCALRmutations can promote oncogenesis by impairing cellular homeostasis and compromising natural and therapy-driven immunosurveillance.

CELL RESEARCH (2021)

Review Immunology

Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Filippo Veglia et al.

Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Medicine, General & Internal

Pembrolizumab for Early Triple-Negative Breast Cancer

Peter Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Pharmacology & Pharmacy

Neoadjuvant or adjuvant chemotherapy in early breast cancer?

Filippo Montemurro et al.

EXPERT OPINION ON PHARMACOTHERAPY (2020)

Review Oncology

Role of Immunotherapy in Triple-Negative Breast Cancer

Tanya E. Keenan et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Review Oncology

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo Galluzzi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Oncology

Lifting the innate immune barriers to antitumor immunity

Carla Rothlin et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Medicine, Research & Experimental

IMMUNEPOTENT CRP plus doxorubicin/cyclophosphamide chemotherapy remodel the tumor microenvironment in an air pouch triple-negative breast cancer murine model

Silvia Elena Santana-Krimskaya et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Oncology

Cellular immunotherapy in breast cancer: The quest for consistent biomarkers

Konstantinos Venetis et al.

CANCER TREATMENT REVIEWS (2020)

Review Immunology

Immunological Significance of HMGB1 Post-Translational Modification and Redox Biology

Man Sup Kwak et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Oncology

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

Lorenzo Galluzzi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

Overview of New Treatments with Immunotherapy for Breast Cancer and a Proposal of a Combination Therapy

Miguel Angel Galvan Morales et al.

MOLECULES (2020)

Article Pharmacology & Pharmacy

Induction of immunogenic cell death of cancer cells through nanoparticle-mediated dual chemotherapy and photothermal therapy

Niloofar Heshmati Aghda et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Oncology

Adjuvant and neoadjuvant therapy for breast cancer

Tadahiko Shien et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Oncology

Triple-negative breast cancer molecular subtyping and treatment progress

Li Yin et al.

BREAST CANCER RESEARCH (2020)

Review Medicine, General & Internal

Recent advances in triple negative breast cancer: the immunotherapy era

Antonio Marra et al.

BMC MEDICINE (2019)

Article Biochemistry & Molecular Biology

The Role of HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases

Mao Wang et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Pathology

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

Joel Zindel et al.

Annual Review of Pathology-Mechanisms of Disease (2019)

Review Oncology

Immunotherapy in HER2-positive breast cancer: state of the art and future perspectives

E. Krasniqi et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Cell Biology

Tuberculosis following PD-1 blockade for cancer immunotherapy

Daniel L. Barber et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Oncology

Checkpoint inhibitors in breast cancer - Current status

Anne Polk et al.

CANCER TREATMENT REVIEWS (2018)

Article Multidisciplinary Sciences

Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells

Debangshu Samanta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Oncology

Expression of NK Cell Surface Receptors in Breast Cancer Tissue as Predictors of Resistance to Antineoplastic Treatment

Garcia-Chagollan Mariel et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2018)

Review Cell Biology

Linking cellular stress responses to systemic homeostasis

Lorenzo Galluzzi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Medicine, General & Internal

Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer

P. Schmid et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

Review Biology

Awareness and current knowledge of breast cancer

Muhammad Akram et al.

BIOLOGICAL RESEARCH (2017)

Review Oncology

Targeting neoantigens to augment antitumour immunity

Mark Yarchoan et al.

NATURE REVIEWS CANCER (2017)

Review Immunology

Immunogenic cell death in cancer and infectious disease

Lorenzo Galluzzi et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Article Oncology

Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer

Rashmi Verma et al.

BREAST CANCER RESEARCH (2016)

Review Medicine, General & Internal

Progress in adjuvant chemotherapy for breast cancer: an overview

Jesus Anampa et al.

BMC MEDICINE (2015)

Editorial Material Oncology

Tumor-infiltrating lymphocytes in breast cancer A new predictor for responses to therapy

Yasmin Issa-Nummer et al.

ONCOIMMUNOLOGY (2014)

Article Medicine, General & Internal

Plasma HMGB-1 after the initial dose of epirubicin/docetaxel in cancer

Tobias Arnold et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Oncology

Regulatory T cells increase in breast cancer and in stage IV breast cancer

Zhi-kuan Wang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

Article Immunology

CD4+Foxp3+ Regulatory T-cell Impairment by Paclitaxel is Independent of Toll-like Receptor 4

Y. Zhu et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2011)

Article Biochemistry & Molecular Biology

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β-dependent adaptive immunity against tumors

Francois Ghiringhelli et al.

NATURE MEDICINE (2009)