4.8 Article

Identification and Validation of 17-lncRNA Related to Regulatory T Cell Heterogeneity as a Prognostic Signature for Head and Neck Squamous Cell Carcinoma

Related references

Note: Only part of the references are listed.
Article Immunology

Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy

Yoshihiro Takasato et al.

Summary: Oral immunotherapy (OIT) is an effective approach to controlling food allergy, but the detailed mechanisms are still unknown. Research has shown that desensitization modulates the activation of mast cells, leading to enhanced expansion of regulatory T cells and promotion of clinical allergic unresponsiveness.

MUCOSAL IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Alternative splicing events implicated in carcinogenesis and prognosis of thyroid gland cancer

Zeng-Hong Wu et al.

Summary: Alternative splicing (AS) is a critical post-transcriptional regulatory mechanism that increases protein diversity by expanding gene expression patterns. In this study, an all-around AS profile of thyroid cancer cells was drawn based on RNA-seq data, revealing that ASEs are common in TC. Additionally, 1819 AS signatures were significantly associated with the overall survival of TC patients, with seven types of ASEs linked to poor prognosis of TC.

SCIENTIFIC REPORTS (2021)

Article Oncology

Extracellular HMGB1 blockade inhibits tumor growth through profoundly remodeling immune microenvironment and enhances checkpoint inhibitor-based immunotherapy

Pascale Hubert et al.

Summary: In this study, it was demonstrated that targeting extracellular HMGB1 can significantly remodel the tumor immune microenvironment for more effective cancer therapy. Inhibition of HMGB1 led to reductions in immunosuppressive cells, such as myeloid-derived suppressor cells and regulatory T lymphocytes, while also enhancing the activation of immune cells like dendritic cells. Additionally, blocking HMGB1 improved the efficacy of anti-PD-1 cancer immunotherapy, suggesting that extracellular HMGB1 blockade could enhance current cancer immunotherapies.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Article Immunology

Clinical Significance and Immunologic Landscape of a Five-IL(R)-Based Signature in Lung Adenocarcinoma

Tao Fan et al.

Summary: This study investigated the expression profile of IL(R) family genes in LUAD and constructed a robust prognostic IL(R)-based signature with strong predictive ability for immunotherapy response. The signature presented unique immune inflammation characteristics in the tumor microenvironment, providing potential for individualized treatment of LUAD.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Prognosis and Characterization of Immune Microenvironment in Acute Myeloid Leukemia Through Identification of an Autophagy-Related Signature

Denggang Fu et al.

Summary: This study identified an autophagy-related signature to monitor the prognosis of AML patients, established a prognostic signature comprising eight autophagy-related genes, and found high-risk patients had significantly shorter overall survival than low-risk patients. The signature could serve as an independent prognostic predictor and was validated on two external AML datasets.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Nuclear Factor Kappa B Signaling Complexes in Acute Inflammation

Sergio Rius-Perez et al.

ANTIOXIDANTS & REDOX SIGNALING (2020)

Article Biotechnology & Applied Microbiology

Identification and validation of immune-related lncRNA prognostic signature for breast cancer

Yong Shen et al.

GENOMICS (2020)

Article Biotechnology & Applied Microbiology

Identification of a Seven-lncRNA Immune Risk Signature and Construction of a Predictive Nomogram for Lung Adenocarcinoma

Donghui Jin et al.

BIOMED RESEARCH INTERNATIONAL (2020)

Article Biochemistry & Molecular Biology

Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer

David Y. Oh et al.

Article Multidisciplinary Sciences

Identification of human CD4+ T cell populations with distinct antitumor activity

Michelle H. Nelson et al.

SCIENCE ADVANCES (2020)

Review Cell Biology

The Roles of CD8(+) T Cell Subsets in Antitumor Immunity

Michael St Paul et al.

TRENDS IN CELL BIOLOGY (2020)

Article Medicine, Research & Experimental

Identification and validation of stemness-related lncRNA prognostic signature for breast cancer

Xiaoying Li et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Medicine, Research & Experimental

Immune-related lncRNAs as predictors of survival in breast cancer: a prognostic signature

Wei Ma et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Review Medicine, General & Internal

Head and Neck Cancer

Laura Q. M. Chow

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Expression of CD4+CD25+CD127Low regulatory T cells and cytokines in peripheral blood of patients with primary liver carcinoma

Wenchao Zhou et al.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2020)

Review Oncology

CD8+ T cell states in human cancer: insights from single-cell analysis

Anne M. Van der Leun et al.

NATURE REVIEWS CANCER (2020)

Article Oncology

LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus

Yingying Jiang et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Review Immunology

Macrophages as regulators of tumour immunity and immunotherapy

David G. DeNardo et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Review Multidisciplinary Sciences

Regulatory T cells: a potential target in cancer immunotherapy

Kohei Shitara et al.

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (2018)

Review Immunology

CD4+ T cell help in cancer immunology and immunotherapy

Jannie Borst et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

NF-κB c-Rel Is Crucial for the Regulatory T Cell Immune Checkpoint in Cancer

Yenkel Grinberg-Bleyer et al.

Article Health Care Sciences & Services

Time-dependent ROC curve analysis in medical research: current methods and applications

Adina Najwa Kamarudin et al.

BMC MEDICAL RESEARCH METHODOLOGY (2017)

Article Biochemistry & Molecular Biology

Two FOXP3+CD4+ T cell subpopulations distinctly control the prognosis of colorectal cancers

Takuro Saito et al.

NATURE MEDICINE (2016)

Article Biochemical Research Methods

Robust enumeration of cell subsets from tissue expression profiles

Aaron M. Newman et al.

NATURE METHODS (2015)

Article Multidisciplinary Sciences

Pirin is an iron-dependent redox regulator of NF-κB

Fange Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Immunology

Regulatory T cells, tumour immunity and immunotherapy

WP Zou

NATURE REVIEWS IMMUNOLOGY (2006)

Review Oncology

The impact of CD4+CD25+ Treg on tumor specific CD8+ T cell cytotoxicity and cancer

K Khazaie et al.

SEMINARS IN CANCER BIOLOGY (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)