☆ 4.8 Article

Robust Antibody Levels in Both Diabetic and Non-Diabetic Individuals After BNT162b2 mRNA COVID-19 Vaccination

FRONTIERS IN IMMUNOLOGY (2021)

Related references

Note: Only part of the references are listed.

Editorial Material Endocrinology & Metabolism

Are people with uncontrolled diabetes mellitus at high risk of reinfections with COVID-19?

Rimesh Pal et al.

Summary: There have been cases of positive real time-polymerase chain reaction (RT-PCR) results (known as "re-positives") after recovery from COVID-19, which could be due to the high false-negative rate of RT-PCR rather than true reinfection. However, in symptomatic patients, the possibility of reactivation or true reinfection remains. People with uncontrolled diabetes mellitus may be at higher risk of reinfections with COVID-19 due to impaired immune responses. Multiple cases of re-positives/re-infections in individuals with diabetes mellitus have been reported.

PRIMARY CARE DIABETES (2021)

Add to Collection

Article Multidisciplinary Sciences

Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma

Kenji Maeda et al.

Summary: This study found that approximately 62.8% of COVID-19 convalescent patients had significant neutralizing activity in their plasma, inhibiting SARS-CoV-2 infection, while around 37.2% did not show neutralizing activity. Patients' neutralizing activity declined rapidly, but SARS-CoV-2-S1-binding antibodies remained consistently present.

SCIENTIFIC REPORTS (2021)

Add to Collection

Review Immunology

Immune Response to SARS-CoV-2 Infection in Obesity and T2D: Literature Review

Jorge Perez-Galarza et al.

Summary: Metabolic diseases such as obesity and diabetes can disrupt the balance of the immune system, leading to stronger immune responses in patients infected with SARS-CoV-2, increasing their risk of severe and fatal outcomes.

VACCINES (2021)

Add to Collection

Article Medical Laboratory Technology

Comprehensive assessment of humoral response after Pfizer BNT162b2 mRNA Covid-19 vaccination: a three-case series

Elisa Danese et al.

Summary: The BNT162b2 mRNA vaccine elicits a strong humoral immune response, particularly involving anti-SARS-CoV-2 IgG and IgA, which is further amplified by the second vaccine dose.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Antibody responses to the BNT162b2 mRNA vaccine in individuals previously infected with SARS-CoV-2

Joseph E. Ebinger et al.

Summary: Virus-specific antibody levels after a single dose of the BNT162b2 vaccine in individuals previously infected with SARS-CoV-2 are similar to levels after two doses of the vaccine in infection-naive individuals. Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomology was similar between groups after the second dose.

NATURE MEDICINE (2021)

Add to Collection

Article Immunology

Immune Response to COVID-19 mRNA Vaccine-A Pilot Study

Andrzej Lange et al.

Summary: The study found that individuals who had a history of COVID-19 were more likely to experience unwanted effects after receiving the BioNTech Pfizer mRNA vaccine and had higher levels of IgA antibodies. Those who had experienced COVID-19 showed stronger responses in terms of nucleocapsid and S2 antibodies.

VACCINES (2021)

Add to Collection

Article Medical Laboratory Technology

Antibody response to first and second dose of BNT162b2 in a cohort of characterized healthcare workers

Andrea Padoan et al.

Summary: The study found significant differences in antibody levels at day 12 after receiving the BNT162b2 vaccine between infection-naive individuals and those with previous natural infection, but no differences were observed thereafter. There were no statistically significant differences between males and females, while individuals over 60 years of age had lower antibody levels at day 12 but not at day 28. The influence of sex and age on vaccine responses warrants further investigation, with age showing particular significance.

CLINICA CHIMICA ACTA (2021)

Add to Collection

Article Multidisciplinary Sciences

Human IgG and IgA responses to COVID-19 mRNA vaccines

Adam Wisnewski et al.

Summary: Study on 4 subjects showed that COVID-19 mRNA vaccines effectively induce spike antigen-specific IgG and IgA, but there are marked differences in their persistence in serum.

PLOS ONE (2021)

Add to Collection

Article Multidisciplinary Sciences

COVID-19 mRNA vaccine induced antibody responses against three SARS-CoV-2 variants

Pinja Jalkanen et al.

Summary: The study shows that the second dose of the BNT162b2 vaccine can induce cross-neutralization to some extent of SARS-CoV-2 variants, providing partial protection. Despite the reduced neutralization effect on the B.1.351 variant, the majority of vaccinees still have some level of protection.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Immunology

BNT162b2 mRNA SARS-CoV-2 Vaccine Elicits High Avidity and Neutralizing Antibodies in Healthcare Workers

Federico Pratesi et al.

Summary: The study found that the BNT162b2 vaccine can induce high levels of antibody response in vaccinated individuals, including IgG and IgA antibodies, as well as antibodies with high avidity. Additionally, the research indicates that levels of neutralizing antibodies significantly increase after the booster dose of the BNT162b2 vaccine.

VACCINES (2021)

Add to Collection

Article Medicine, General & Internal

Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine

Raul Pellini et al.

Summary: The study found that 99.5% of healthcare workers developed a humoral immune response after vaccination, with female and young participants showing an increased capacity for humoral immune responses. Body mass index and hypertension seem to have no association with the differences in immune response to the vaccine.

ECLINICALMEDICINE (2021)

Add to Collection

Article Endocrinology & Metabolism

COVID-19 vaccination in patients with diabetes mellitus: Current concepts, uncertainties and challenges

Rimesh Pal et al.

Summary: This study summarized the evidence on the use of COVID-19 vaccines in patients with diabetes mellitus, highlighting the poor prognosis of COVID-19 in diabetic patients and the importance of prioritizing vaccination. However, there are still unresolved issues regarding COVID-19 vaccination that need to be addressed in future research.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

Add to Collection

Article Multidisciplinary Sciences

Clinical characteristics and outcomes of COVID-19 patients with diabetes mellitus in Kuwait

Abdullah Alshukry et al.

Summary: Patients with diabetes and COVID-19 have higher rates of ICU admission and mortality compared to those without diabetes. Increasing fasting blood glucose levels in COVID-19 patients are associated with higher odds of death.

HELIYON (2021)

Add to Collection

Article Endocrinology & Metabolism

Impaired anti-SARS-CoV-2 antibody response in non-severe COVID-19 patients with diabetes mellitus: A preliminary report

Rimesh Pal et al.

Summary: This study compared anti-SARS-CoV-2 antibody responses in non-severe COVID-19 patients with and without type 2 diabetes mellitus, revealing that patients with diabetes were more likely to have undetectable antibodies, potentially increasing their risk of reinfection. Further large-scale studies are needed to validate these findings.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2021)

Add to Collection

Letter Infectious Diseases

An interactive web-based dashboard to track COVID-19 in real time

Ensheng Dong et al.

LANCET INFECTIOUS DISEASES (2020)

Add to Collection

Review Immunology

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

Gholamreza Daryabor et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Immunology

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

Yujun Tang et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

Luca Piccoli et al.

CELL (2020)

Add to Collection

Article Endocrinology & Metabolism

Fasting Blood Glucose and COVID-19 Severity: Nonlinearity Matters

Barrak Alahmad et al.

DIABETES CARE (2020)

Add to Collection

Article Endocrinology & Metabolism

Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study

Vito Lampasona et al.

DIABETOLOGIA (2020)

Add to Collection

Article Multidisciplinary Sciences

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Ugur Sahin et al.

NATURE (2020)

Add to Collection

Article Medicine, General & Internal

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

Edward E. Walsh et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines

Antonella Fara et al.

OPEN BIOLOGY (2020)

Add to Collection

Article Microbiology

Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

Jeffrey Seow et al.

NATURE MICROBIOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Clinical characteristics of coronavirus disease 2019 (COVID-19) patients in Kuwait

Abdullah Alshukry et al.

PLOS ONE (2020)

Add to Collection

Review Immunology

Impact of Diabetes in Patients Diagnosed With COVID-19

Mohamed Abu-Farha et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Innate immune activation in obesity

Carey N. Lumeng

MOLECULAR ASPECTS OF MEDICINE (2013)

Add to Collection

Article Biochemistry & Molecular Biology

The implication of proinflammatory cytokines in type 2 diabetes

Christopher B. Guest et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

Add to Collection

© Peeref 2019-2024. All rights reserved.