Related references
Note: Only part of the references are listed.Application of T cell receptor (TCR) repertoire analysis for the advancement of cancer immunotherapy
Kroopa Joshi et al.
CURRENT OPINION IN IMMUNOLOGY (2022)
Human islet T cells are highly reactive to preproinsulin in 1 diabetes
Amanda M. Anderson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
T-cell responses to hybrid insulin peptides prior to type 1 diabetes development
Angela M. Mitchell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
DeepTCR is a deep learning framework for revealing sequence concepts within T-cell repertoires
John-William Sidhom et al.
NATURE COMMUNICATIONS (2021)
TCRMatch: Predicting T-Cell Receptor Specificity Based on Sequence Similarity to Previously Characterized Receptors
William D. Chronister et al.
FRONTIERS IN IMMUNOLOGY (2021)
Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors
Laurie G. Landry et al.
FRONTIERS IN ENDOCRINOLOGY (2021)
The Vbeta13 T Cell Receptor Monoclonal Antibody Reduces Hyaluronan and CD68+, CD3+, and CD8+Cell Infiltrations to Delay Diabetes in Congenic BB DRLyp/Lyp Rats
Marika Bogdani et al.
FRONTIERS IN ENDOCRINOLOGY (2021)
A framework for highly multiplexed dextramer mapping and prediction of T cell receptor sequences to antigen specificity
Wen Zhang et al.
SCIENCE ADVANCES (2021)
High-throughput and single-cell T cell receptor sequencing technologies
Joy A. Pai et al.
NATURE METHODS (2021)
Immunotherapy: Building a bridge to a cure for type 1 diabetes
Jeffrey A. Bluestone et al.
SCIENCE (2021)
T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8
Mai T. Tran et al.
NATURE COMMUNICATIONS (2021)
GIANA allows computationally-efficient TCR clustering and multi-disease repertoire classification by isometric transformation
Hongyi Zhang et al.
NATURE COMMUNICATIONS (2021)
T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes
John P. Mordes et al.
GENES (2021)
Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?
Teresa Rodriguez-Calvo et al.
FRONTIERS IN IMMUNOLOGY (2021)
Characterization of Human CD4 T Cells Specific for a C-Peptide/C-Peptide Hybrid Insulin Peptide
Timothy A. Wiles et al.
FRONTIERS IN IMMUNOLOGY (2021)
Multiplex T-cell Stimulation Assay Utilizing a T-cell Activation Reporter- based Detection System
Laurie G. Landry et al.
BIO-PROTOCOL (2021)
VDJbase: an adaptive immune receptor genotype and haplotype database
Aviv Omer et al.
NUCLEIC ACIDS RESEARCH (2020)
VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium
Dmitry Bagaev et al.
NUCLEIC ACIDS RESEARCH (2020)
Investigation of Antigen-Specific T-Cell Receptor Clusters in Human Cancers
Hongyi Zhang et al.
CLINICAL CANCER RESEARCH (2020)
Peripheral CD8+ T cell characteristics associated with durable responses to immune checkpoint blockade in patients with metastatic melanoma
Benjamin P. Fairfax et al.
NATURE MEDICINE (2020)
Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System
Sarah E. Mann et al.
FRONTIERS IN IMMUNOLOGY (2020)
Analyzing the Mycobacterium tuberculosis immune response by T-cell receptor clustering with GLIPH2 and genome-wide antigen screening
Huang Huang et al.
NATURE BIOTECHNOLOGY (2020)
T cell receptor sequence clustering and antigen specificity
Milena Vujovic et al.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)
T-cell receptor repertoire analysis for the diagnosis and treatment of solid tumor: A methodology and clinical applications
Na Li et al.
CANCER COMMUNICATIONS (2020)
De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection
Daria Beshnova et al.
SCIENCE TRANSLATIONAL MEDICINE (2020)
Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
Chloe H. Lee et al.
FRONTIERS IN IMMUNOLOGY (2020)
The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
Christine Bender et al.
SCIENCE ADVANCES (2020)
Standardizing T-Cell Biomarkers in Type 1 Diabetes: Challenges and Recent Advances
Simi Ahmed et al.
DIABETES (2019)
Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes
Rocky L. Baker et al.
DIABETES (2019)
How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes
Yang Wang et al.
SCIENCE IMMUNOLOGY (2019)
Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset
Louis Gioia et al.
SCIENCE IMMUNOLOGY (2019)
The Immune Epitope Database (IEDB): 2018 update
Randi Vita et al.
NUCLEIC ACIDS RESEARCH (2019)
VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
Mikhail Shugay et al.
NUCLEIC ACIDS RESEARCH (2018)
Genetics of type 1 diabetes
Catherine C. Robertson et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2018)
Human T Cell Development, Localization, and Function throughout Life
Brahma V. Kumar et al.
IMMUNITY (2018)
iReceptor: A platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories
Brian D. Corrie et al.
IMMUNOLOGICAL REVIEWS (2018)
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
Louise F. Risnes et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Development of T cell lines sensitive to antigen stimulation
Theodore Williams et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2018)
Proinsulin C-peptide is an autoantigen in people with type 1 diabetes
Michelle So et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors
Slobodan Culina et al.
SCIENCE IMMUNOLOGY (2018)
Understanding the drivers of MHC restriction of T cell receptors
Nicole L. La Gruta et al.
NATURE REVIEWS IMMUNOLOGY (2018)
Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes
Aaron W. Michels et al.
DIABETES (2017)
Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes
Karen Cerosaletti et al.
JOURNAL OF IMMUNOLOGY (2017)
Quantifiable predictive features define epitope-specific T cell receptor repertoires
Pradyot Dash et al.
NATURE (2017)
Identifying specificity groups in the T cell receptor repertoire
Jacob Glanville et al.
NATURE (2017)
Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes
Maria J. L. Kracht et al.
NATURE MEDICINE (2017)
Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+T cell epitope
InYoung Song et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
T cell receptor sequencing of early-stage breast cancer tumors identifies altered clonal structure of the T cell repertoire
John F. Beausang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Type 1 diabetes induction in humanized mice
Shulian Tan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+T cell epitope
InYoung Song et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
CD8+ T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage
Yannick F. Fuchs et al.
SCIENTIFIC REPORTS (2017)
Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis
Alexandra Snyder et al.
PLOS MEDICINE (2017)
Avidity and Bystander Suppressive Capacity of Human Regulatory T Cell Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes
Wen-I Yeh et al.
FRONTIERS IN IMMUNOLOGY (2017)
Type 1 diabetes mellitus
Anastasia Katsarou et al.
NATURE REVIEWS DISEASE PRIMERS (2017)
T Cell Receptor Profiling in Type 1 Diabetes
Laura M. Jacobsen et al.
CURRENT DIABETES REPORTS (2017)
McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences
Nili Tickotsky et al.
BIOINFORMATICS (2017)
repgenHMM: a dynamic programming tool to infer the rules of immune receptor generation from sequence data
Yuval Elhanati et al.
BIOINFORMATICS (2016)
Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects
Nadeem Sheikh et al.
CANCER RESEARCH (2016)
HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression
Alberto Pugliese et al.
DIABETES (2016)
How many TCR clonotypes does a body maintain?
Grant Lythe et al.
JOURNAL OF THEORETICAL BIOLOGY (2016)
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Jenny Aurielle B. Babon et al.
NATURE MEDICINE (2016)
Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
Thomas Delong et al.
SCIENCE (2016)
T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients
Yin Tong et al.
GENOMICS PROTEOMICS & BIOINFORMATICS (2016)
Incomplete immune response to coxsackie B viruses associates with early autoimmunity against insulin
Michelle P. Ashton et al.
SCIENTIFIC REPORTS (2016)
Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes
Howard R. Seay et al.
JCI INSIGHT (2016)
T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules
Jamie Rossjohn et al.
ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)
Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice
J. Babad et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2015)
High Diversity in the TCR Repertoire of GAD65 Autoantigen-Specific Human CD4+ T Cells
Anne Eugster et al.
JOURNAL OF IMMUNOLOGY (2015)
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
Xinli Hu et al.
NATURE GENETICS (2015)
Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects
Maki Nakayama et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
A run on the biobank: what have we learned about type 1 diabetes from the nPOD tissue repository?
John S. Kaddis et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2015)
Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer-Restricted CD4(+) T Cells Infiltrate Islets in Type 1 Diabetes
Vimukthi Pathiraja et al.
DIABETES (2015)
β-Cell-Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure
Ania Skowera et al.
DIABETES (2015)
Deletion of Both Rab-GTPase-Activating Proteins TBC14KO and TBC1D4 in Mice Eliminates Insulin- and AICAR-Stimulated Glucose Transport
Alexandra Chadt et al.
DIABETES (2015)
PD-1 blockade induces responses by inhibiting adaptive immune resistance
Paul C. Tumeh et al.
NATURE (2014)
Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes
Junbao Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Diversity and clonal selection in the human T-cell repertoire
Qian Qi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Human memory T cells: generation, compartmentalization and homeostasis
Donna L. Farber et al.
NATURE REVIEWS IMMUNOLOGY (2014)
Pathogenic CD4+ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes
James F. Mohan et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
A Novel Approach to Tracking Antigen-Experienced CD4 T Cells into Functional Compartments via Tandem Deep and Shallow TCR Clonotyping
Megan Estorninho et al.
JOURNAL OF IMMUNOLOGY (2013)
Respiratory Infections in Early Life and the Development of Islet Autoimmunity in Children at Increased Type 1 Diabetes Risk Evidence From the BABYDIET Study
Andreas Beyerlein et al.
JAMA PEDIATRICS (2013)
Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire
Veronika I. Zarnitsyna et al.
FRONTIERS IN IMMUNOLOGY (2013)
Prevention of Type 1 Diabetes in the Rat With an Allele-Specific Anti T-Cell Receptor Antibody Vβ13 as a Therapeutic Target and Biomarker
Zhijun Liu et al.
DIABETES (2012)
Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice
Maki Nakayama et al.
DIABETES (2012)
Circulating Preproinsulin Signal Peptide-Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells
Deborah Kronenberg et al.
DIABETES (2012)
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes
Martha Campbell-Thompson et al.
DIABETES-METABOLISM RESEARCH AND REVIEWS (2012)
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
Ken T. Coppieters et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLAA2 Transgenic NOD/SCID/IL2RG Null Mice
Wendy W. J. Unger et al.
PLOS ONE (2012)
Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers
Wendy W. Unger et al.
JOURNAL OF AUTOIMMUNITY (2011)
TCR Bias of In Vivo Expanded T Cells in Pancreatic Islets and Spleen at the Onset in Human Type 1 Diabetes
Eva Codina-Busqueta et al.
JOURNAL OF IMMUNOLOGY (2011)
On the Composition of the Preimmune Repertoire of T Cells Specific for Peptide-Major Histocompatibility Complex Ligands
Marc K. Jenkins et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 (2010)
HLA Class I and Genetic Susceptibility to Type 1 Diabetes Results From the Type 1 Diabetes Genetics Consortium
Janelle A. Noble et al.
DIABETES (2010)
Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes The Diabetes and Autoimmunity Study in the Young (DAISY)
Lars C. Stene et al.
DIABETES (2010)
Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression
Timothy I. M. Tree et al.
DIABETES (2010)
Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes
James F. Mohan et al.
NATURE IMMUNOLOGY (2010)
Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells
Harlan S. Robins et al.
BLOOD (2009)
Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains
Li Zhang et al.
JOURNAL OF AUTOIMMUNITY (2009)
Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor
David K. Cole et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Restricted Autoantigen Recognition Associated with Deletional and Adaptive Regulatory Mechanisms
John A. Gebe et al.
JOURNAL OF IMMUNOLOGY (2009)
Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus
John P. Mordes et al.
MAMMALIAN GENOME (2009)
Genetics of Type 1A Diabetes
Patrick Concannon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Evolutionarily conserved amino acids that control TCR-MHC interaction
Philippa Marrack et al.
ANNUAL REVIEW OF IMMUNOLOGY (2008)
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: Analysis of the Type 1 Diabetes Genetics Consortium families
Henry Erlich et al.
DIABETES (2008)
The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its vβ domain
Jeffrey Ishizuka et al.
IMMUNITY (2008)
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
Ania Skowera et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Conserved T cell receptor α-chain induces insulin autoantibodies
Masakazu Kobayashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
Sergey Nejentsev et al.
NATURE (2007)
The insulin-specific T cells of nonobese diabetic mice recognize a weak MHC-binding segment in more than one form
Matteo G. Levisetti et al.
JOURNAL OF IMMUNOLOGY (2007)
Human TCR-Binding affinity is governed by MHC class restriction
David K. Cole et al.
JOURNAL OF IMMUNOLOGY (2007)
Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes
J Endl et al.
DIABETES (2006)
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope
SC Kent et al.
NATURE (2005)
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
S Lindley et al.
DIABETES (2005)
GAD65-Specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes
H Reijonen et al.
DIABETES (2004)
Rat models of type 1 diabetes: Genetics, environment, and autoimmunity
JP Mordes et al.
ILAR JOURNAL (2004)
Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes
SM Lieberman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
A polymorphism of the rat T-cell receptor β-chain variable gene 13 (BV13S1) correlates with the frequency of BV13S1-positive CD4 cells
M Stienekemeier et al.
IMMUNOGENETICS (2000)
Dual overlapping peptides recognized by insulin peptide B:9-23 T cell receptor AV13S3 T cell clones of the NOD mouse
N Abiru et al.
JOURNAL OF AUTOIMMUNITY (2000)