Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.806560
Keywords
systemic lupus erythematosus (SLE); immunometabolism; mitochondria; lipid metabolism; T cell; B cell; monocyte; autoimmunity
Categories
Funding
- Lupus UK [M409]
- Rosetrees Trust [M409]
- Cure JM
- GOS BRC
- Versus Arthritis [21992, 22600]
- Lupus UK
- Rosetrees Trust [M409] Funding Source: researchfish
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Upregulation of cellular energy metabolism plays a crucial role in the immune response of SLE. The latest research has found a close connection between abnormal mitochondrial function, lipid metabolism, and mTOR signaling with the immunological phenomenon observed in SLE. These findings have important implications for future therapeutic options in managing the disease.
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder in which pathogenic abnormalities within both the innate and adaptive immune response have been described. In order to activated, proliferate and maintain this immunological response a drastic upregulation in energy metabolism is required. Recently, a greater understanding of these changes in cellular bioenergetics have provided new insight into the links between immune response and the pathogenesis of a number of diseases, ranging from cancer to diabetes and multiple sclerosis. In this review, we highlight the latest understanding of the role of immunometabolism in SLE with particular focus on the role of abnormal mitochondrial function, lipid metabolism, and mTOR signaling in the immunological phenomenon observed in the SLE. We also consider what implications this has for future therapeutic options in the management of the disease in future.
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