4.8 Review

The COVID-19/Tuberculosis Syndemic and Potential Antibody Therapy for TB Based on the Lessons Learnt From the Pandemic

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

Laura A. VanBlargan et al.

Summary: The emergence of the B.1.1.529 Omicron variant raises concerns about the efficacy of antibody countermeasures. This study shows that some of the antibodies currently in clinical use may lose their ability to neutralize the Omicron variant.

NATURE MEDICINE (2022)

News Item Critical Care Medicine

Omicron variant and booster COVID-19 vaccines

Talha Khan Burki

LANCET RESPIRATORY MEDICINE (2022)

Article Biophysics

COVID-19 diagnosis - A review of current methods

Meral Yuce et al.

Summary: A fast and accurate self-testing tool for COVID-19 diagnosis is crucial for understanding the global situation and taking appropriate actions. The diagnosis tools available mainly rely on viral gene detection, human antibody detection, and viral antigen detection, with RT-PCR being the most reliable technique.

BIOSENSORS & BIOELECTRONICS (2021)

Review Pediatrics

The potential impact of the COVID-19 pandemic on child growth and development: a systematic review

Liubiana Arantes de Araujo et al.

Summary: Research indicates that epidemics can lead to high levels of stress in parents and children, affecting child development and health. Parents and children may experience severe anxiety, depression, and other emotional issues, which may be related to adverse childhood experiences and increased risk of toxic stress.

JORNAL DE PEDIATRIA (2021)

Article Medicine, General & Internal

Pulmonary embolism, transient ischaemic attack and thrombocytopenia after the Johnson & Johnson COVID-19 vaccine

Bilal Malik et al.

Summary: This study reports a case of a 43-year-old woman who developed a thrombotic event after receiving the J&J COVID-19 vaccine. It is recommended that patients be informed of the potential for such events to occur in order to obtain informed consent.

BMJ CASE REPORTS (2021)

Article Medicine, General & Internal

Guillain-Barre syndrome after COVID-19 vaccination

Norma McKean et al.

Summary: The correlation between COVID-19 infection/vaccination and GBS remains unclear, requiring ongoing assessment of risks. The specific presentation of bifacial weakness as a symptom of GBS may be related to COVID-19 vaccination.

BMJ CASE REPORTS (2021)

Article Medicine, General & Internal

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19 A Randomized Clinical Trial

Robert L. Gottlieb et al.

Summary: The study showed that treatment with bamlanivimab and etesevimab was significantly associated with a reduction in SARS-CoV-2 viral load at day 11 in nonhospitalized patients with mild to moderate COVID-19, compared to placebo. However, bamlanivimab monotherapy did not show a significant reduction in viral load. Ongoing clinical trials will focus on assessing the clinical benefits of antispike neutralizing antibodies in COVID-19 patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Editorial Material Medicine, General & Internal

Oxford-AstraZeneca COVID-19 vaccine efficacy

Maria Deloria Knoll et al.

LANCET (2021)

Article Medicine, General & Internal

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

D. M. Weinreich et al.

Summary: Recent data indicate that complications and death from Covid-19 may be related to high viral loads. In this trial involving nonhospitalized patients, a cocktail of two neutralizing monoclonal antibodies (REGN-COV2) reduced viral load, with a greater effect in patients with no immune response or high viral load at baseline. Safety outcomes were similar between REGN-COV2 dose groups and the placebo group.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

Peter Chen et al.

Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Physiology

Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes

Sundareswaran Loganathan et al.

Summary: COVID-19 mainly affects the lungs, progressing to pneumonia and acute respiratory distress syndrome (ARDS) through the ACE2 receptor, spreading to various organs. Cytokine storm aggravates inflammation, leading to multiple organ dysfunction. This study provides insights for clinicians and scientists to combat COVID-19.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY (2021)

Review Immunology

Pathology of TB/COVID-19 Co-Infection: The phantom menace

Gabriel Tassi Mousquer et al.

Summary: Tuberculosis and COVID-19 are the leading causes of death among infectious diseases, with co-infection potentially causing immune system imbalance and exacerbating disease progression. Understanding the interactions between Mycobacterium tuberculosis and SARS-CoV-2 is crucial for developing therapeutic strategies against co-infection.

TUBERCULOSIS (2021)

Review Cell Biology

Developing New Anti-Tuberculosis Vaccines: Focus on Adjuvants

Ana Rita Franco et al.

Summary: Tuberculosis is a major global health concern, and new vaccines are needed to overcome the limitations of the current BCG vaccine. The World Health Organization considers the development of new TB vaccines to be a top priority, with subunit vaccines being promising candidates that may require adjuvants to enhance their efficacy.

CELLS (2021)

Review Respiratory System

Tuberculosis and COVID-19 interaction: A review of biological, clinical and public health effects

D. Visca et al.

Summary: This review aims to report the available evidence on the interaction between tuberculosis (TB) and COVID-19, discussing their differences and similarities, immunological features, diagnostics, epidemiological and clinical characteristics, as well as public health implications. The shared dysregulation of immune responses in COVID-19 and TB poses a dual risk, and further evidence is needed to determine the impact of COVID-19 on active TB disease. Ongoing studies are expected to provide additional evidence on the potential risks and interactions between the two diseases.

PULMONOLOGY (2021)

Editorial Material Medicine, General & Internal

Omicron SARS-CoV-2 variant: a new chapter in the COVID-19 pandemic

Salim S. Abdool Karim et al.

LANCET (2021)

Article Medicine, General & Internal

BNT162b2 Vaccine Booster and Mortality Due to Covid-19

Ronen Arbel et al.

Summary: Among 843,208 participants in Israel aged 50 years or older who had received two doses of the BNT162b2 vaccine at least 5 months earlier, those who received a booster had 90% lower mortality due to Covid-19 than those who did not receive a booster during the 54-day study period.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

Yanjun Zhang et al.

Summary: This study investigated the safety, tolerability, and immunogenicity of the COVID-19 vaccine candidate CoronaVac, and found that the 3 μg dose showed higher seroconversion rates in the phase 2 trial.

LANCET INFECTIOUS DISEASES (2021)

Article Immunology

NIH funding for vaccine readiness before the COVID-19 pandemic

Anthony E. Kiszewski et al.

Summary: This study examines the maturity of COVID-19 vaccine candidate technologies and NIH funding for these technologies, finding that sustained NIH funding plays a crucial role in advancing vaccine technologies. However, vaccine research against specific pandemic threats did not receive sustained funding.

VACCINE (2021)

Article Environmental Sciences

Impact of the COVID-19 Pandemic on the Mental Health of Healthcare Workers

Andreas Chatzittofis et al.

Summary: The COVID-19 pandemic has had significant impacts on the mental health of healthcare workers, leading to symptoms such as post-traumatic stress disorder, anxiety, and depression. Even in countries with relatively low transmission rates, like Cyprus, healthcare workers are reporting substantial mental health burdens, with nurses showing higher levels of depressive and PTSD symptoms compared to other healthcare professionals.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Review Immunology

The BCG Vaccine for COVID-19: First Verdict and Future Directions

Maria Gonzalez-Perez et al.

Summary: Despite the rapid development of SARS-CoV-2 vaccines, widespread vaccination will take time, making BCG a potential interim solution in mitigating the pandemic impact in some countries; the cross-protective effects of BCG vaccine and its mechanism of trained immunity provide potential applications in respiratory infectious diseases and ongoing SARS-CoV-2 clinical trials.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Lipocalin 2 regulates expression of MHC class I molecules in Mycobacterium tuberculosis-infected dendritic cells via ROS production

Ji-Ae Choi et al.

Summary: This study elucidates the role of LCN2 in regulating the expression of MHC class I molecules in immune cells during Mtb infection, subsequently impacting CD8(+) effector T-cell proliferation. LCN2(-/-) mice exhibited lower levels of inflammatory response during Mtb infection.

CELL AND BIOSCIENCE (2021)

Article Public, Environmental & Occupational Health

Case Report: Development of Miliary Pulmonary Tuberculosis in a Patient with Peritoneal Tuberculosis after COVID-19 Upper Respiratory Tract Infection

Moustafa M. Elziny et al.

Summary: This case report presents a 29-year-old patient with COVID-19 and peritoneal tuberculosis without pulmonary involvement. After recovering from COVID-19, the patient developed miliary pulmonary TB, requiring intensive care unit admission and intubation. The patient showed improvement with antitubercular treatment, highlighting the potential rapid progression and worsened outcome when COVID-19 and TB coexist.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2021)

Review Biochemistry & Molecular Biology

Corticosteroids for COVID-19 Therapy: Potential Implications on Tuberculosis

Radha Gopalaswamy et al.

Summary: COVID-19 and TB are two distinct respiratory infectious diseases with similar clinical symptoms, adding to the disease burden globally and influencing host immunity. Individuals with latent TB infection (LTBI) may face the risk of TB reactivation when undergoing corticosteroid therapy for COVID-19.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Reconcile the debate over protective effects of BCG vaccine against COVID-19

Wei Fu et al.

Summary: Research suggests that the BCG vaccine may offer some protection against COVID-19, especially in the early stages of the pandemic, but the effectiveness seems to diminish as the pandemic progresses. The protective effect of BCG vaccination may also vary depending on the age structure of the vaccinated population.

SCIENTIFIC REPORTS (2021)

Review Biotechnology & Applied Microbiology

The potential applications of T cell receptor (TCR)-like antibody in cervical cancer immunotherapy

Sylvia Annabel Dass et al.

Summary: Cervical cancer ranks fourth among common cancers in women worldwide. Monoclonal antibody therapy shows promising potential for targeting various aspects of cervical cancer and creating novel antibody classes like T cell receptor (TCR)-like antibody. Current immunotherapy strategies for cervical cancer, including the concept of TCR-like antibody, face challenges that must be addressed to maximize therapeutic benefits.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

Article Public, Environmental & Occupational Health

COVID-19 Vaccine Second-Dose Completion and Interval Between First and Second Doses Among Vaccinated Persons - United States, December 14, 2020-February 14, 2021

Jennifer L. Kriss et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

Review Biotechnology & Applied Microbiology

Inhalation monoclonal antibody therapy: a new way to treat and manage respiratory infections

Hilal Ahmad Parray et al.

Summary: The route of administration plays a crucial role in the success of therapeutic agents, with inhalation being a promising strategy for treating respiratory diseases by providing higher concentrations of drugs in the respiratory airways and overcoming the limitations of systemic administration.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021)

Article

COVID-19 and pulmonary tuberculosis – A diagnostic dilemma

Som Subhro Biswas et al.

Radiology Case Reports (2021)

Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

News Item Biotechnology & Applied Microbiology

'Super-antibodies' could curb COVID-19 and help avert future pandemics

Elie Dolgin

Summary: Companies are developing next-generation antibodies inspired by unique individuals whose immune systems can neutralize any COVID-19 variant and related coronaviruses.

NATURE BIOTECHNOLOGY (2021)

Article Medicine, General & Internal

Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19

M. Dougan et al.

Summary: In this phase 3 trial, the combination of bamlanivimab plus etesevimab was found to reduce the incidence of Covid-19-related hospitalization and death among high-risk ambulatory patients compared to placebo, and also accelerated the decline in SARS-CoV-2 viral load.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-I

Yiwen Zhang et al.

Summary: COVID-19, caused by SARS-CoV-2, significantly differs from SARS in its clinical and pathological characteristics. The viral protein ORF8 of SARS-CoV-2 interacts with MHC-I molecules, leading to their down-regulation and impairment of antigen presentation system, proposing ORF8 inhibition as a potential strategy for improving immune surveillance.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Multidisciplinary Sciences

Airborne transmission of respiratory viruses

Chia C. Wang et al.

Summary: The COVID-19 pandemic has exposed critical knowledge gaps in our understanding of traditional respiratory virus transmission pathways, highlighting the need for updates. Improved understanding of aerosol transmission through studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection calls for a reassessment of major transmission pathways for other respiratory viruses, enabling better control measures to reduce airborne transmission.

SCIENCE (2021)

Article Cell Biology

SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination

Markus Hoffmann et al.

Summary: The emergence of the B.1.617 variant in India may be responsible for the sharp increase in COVID-19 cases and deaths. B.1.617 shows increased efficiency in entering cells and evades antibody responses, contributing to its rapid spread.

CELL REPORTS (2021)

Article Cell Biology

CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection

Yu-Jung Lu et al.

Summary: CD4 T cells play a crucial role in immunity to tuberculosis by enhancing CD8 effector functions and preventing exhaustion, promoting the survival of infected mice. Vaccines that elicit both CD4 and CD8 T cells are more likely to be successful in generating protective responses against M. tuberculosis infection.

CELL REPORTS (2021)

Article Microbiology

Current status of therapeutic monoclonal antibodies against SARS-CoV-2

Sanjeev Kumar et al.

PLOS PATHOGENS (2021)

Review Immunology

Myeloid-Derived Suppressor Cells as a Potential Biomarker and Therapeutic Target in COVID-19

Marianna Rowlands et al.

Summary: The clinical presentations of COVID-19 are highly variable, and the pathophysiological mechanisms that govern different disease courses are still poorly understood. Severity of COVID-19 may be associated with dysregulation of myeloid-derived suppressor cells (MDSCs). MDSCs play a crucial role in COVID-19 infection by modulating T-cell responses and promoting an inflammatory state through secretion of mediators.

FRONTIERS IN IMMUNOLOGY (2021)

Article Public, Environmental & Occupational Health

The SARS-CoV-2 pandemic: A syndemic perspective

Ines Fronteira et al.

Summary: The COVID-19 pandemic has had a profound impact globally, interacting with existing diseases and social determinants to affect health outcomes and exacerbate social disadvantages. Understanding it as a syndemic issue is crucial for effective policy-making and public health responses.

ONE HEALTH (2021)

Article Medicine, General & Internal

Casirivimab-Imdevimab treatment is associated with reduced rates of hospitalization among high-risk patients with mild to moderate coronavirus disease-19

Raymund R. Razonable et al.

Summary: This study found that among high-risk patients, treatment with casirivimab-imdevimab was associated with significantly lower hospitalization rates.

ECLINICALMEDICINE (2021)

Review Biochemistry & Molecular Biology

Development and application of therapeutic antibodies against COVID-19

Lin Ning et al.

Summary: The global health crisis caused by the COVID-19 pandemic continues, with many therapeutic antibody treatments in development and authorized for emergency use by the FDA. Ongoing clinical trials worldwide have shown therapeutic antibody therapies to be a crucial part of COVID-19 treatment.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Review Biochemistry & Molecular Biology

mRNA vaccines for COVID-19: what, why and how

Jung Woo Park et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to significant impact on human lives, with mRNA vaccines emerging as promising candidates due to their rapid development time, cost-effectiveness, versatility in design, and proven ability to induce immune response.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Review Biochemistry & Molecular Biology

Coagulopathies after Vaccination against SARS-CoV-2 May Be Derived from a Combined Effect of SARS-CoV-2 Spike Protein and Adenovirus Vector-Triggered Signaling Pathways

Ralf Kircheis

Summary: The global pandemic of the novel coronavirus has led to the approval and application of various vaccines, but some rare blood clot side effects have been reported, potentially correlated with interactions between vaccine components and the immune system.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

Petra Mlcochova et al.

Summary: The B.1.617.2 (Delta) variant of SARS-CoV-2 has lower sensitivity to antibodies and higher replication efficiency compared to other lineages, which may contribute to its dominance and reduced vaccine effectiveness, highlighting the need for continued infection control measures post-vaccination.

NATURE (2021)

Article Infectious Diseases

Variances in BCG protection against COVID-19 mortality: A global assessment

Zouina Sarfraz et al.

Summary: The BCG vaccine is known for providing protection against tuberculosis and potential benefits in preventing bladder cancer and respiratory infections. During the COVID-19 pandemic, the BCG vaccine has garnered attention for its potential role in conferring protective immunity. Research has revealed the potential immunological mechanisms of BCG vaccines against COVID-19.

JOURNAL OF CLINICAL TUBERCULOSIS AND OTHER MYCOBACTERIAL DISEASES (2021)

Article Immunology

Effects of Coronavirus Disease Pandemic on Tuberculosis Notifications, Malawi

Rebecca Nzawa Soko et al.

Summary: The COVID-19 pandemic had a significant impact on tuberculosis diagnosis and patient care in Blantyre, Malawi. TB notifications decreased by 35.9% in April 2020 but gradually recovered by December 2020, although still falling short by 333 cases compared to expectations. Women and girls were disproportionately affected, with reasons including fear of COVID-19, temporary facility closures, and lack of personal protective equipment.

EMERGING INFECTIOUS DISEASES (2021)

Article Medicine, Research & Experimental

Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection

Catherine Riou et al.

Summary: This study found that the attributes of SARS-CoV-2-specific CD4(+) T cells were associated with the severity of COVID-19, with severe cases showing poor polyfunctional potential, reduced proliferation capacity, and enhanced HLA-DR expression. HIV-1 and TB coinfection can alter the SARS-CoV-2 T cell response, with HIV-1 causing CD4(+) T cell depletion and active TB leading to decreased polyfunctional capacity of SARS-CoV-2-specific CD4(+) T cells in COVID-19 patients. Moreover, COVID-19 patients displayed a reduced frequency of Mycobacterium tuberculosis-specific CD4(+) T cells, which may affect TB disease progression.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Immunology

Parallels and Mutual Lessons in Tuberculosis and COVID-19 Transmission, Prevention, and Control

Philip C. Hopewell et al.

Summary: The COVID-19 pandemic has had unprecedented negative effects on global health and economies, drawing attention and resources away from other public health services. Identifying parallels, lessons, and resources from existing public health programs can help minimize these effects. There are synergies between COVID-19 and TB in terms of transmission and public health response, which should be prospectively studied for optimal interventions.

EMERGING INFECTIOUS DISEASES (2021)

Review Immunology

Neutralizing monoclonal antibodies for treatment of COVID-19

Peter C. Taylor et al.

Summary: The study discusses the clinical utility of neutralizing monoclonal antibody therapies targeting SARS-CoV-2, emphasizing the importance of patient stratification, biomarkers, risk factors, and other clinical considerations.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Respiratory System

COVID-19 promoting the development of active tuberculosis in a patient with latent tuberculosis infection: A case report

Mohammed Khayat et al.

Summary: A 40-year-old female patient diagnosed with COVID-19 later developed symptoms of pulmonary tuberculosis, suggesting a potential link between COVID-19-induced CD4(+) T-cell depletion and the activation of latent tuberculosis infection. This may have significant implications for the global burden of TB, highlighting the need for early diagnosis and meticulous contact tracing.

RESPIRATORY MEDICINE CASE REPORTS (2021)

Review Microbiology

Tuberculosis Vaccine Development: Progress in Clinical Evaluation

Suraj B. Sable et al.

CLINICAL MICROBIOLOGY REVIEWS (2020)

Review Biotechnology & Applied Microbiology

Recent updates on drug resistance in Mycobacterium tuberculosis

R. Singh et al.

JOURNAL OF APPLIED MICROBIOLOGY (2020)

Review Immunology

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

Hussin A. Rothan et al.

JOURNAL OF AUTOIMMUNITY (2020)

Editorial Material Respiratory System

Pathogenesis of COVID-19 from a cell biology perspective

Robert J. Mason

EUROPEAN RESPIRATORY JOURNAL (2020)

Letter Virology

COVID-19 in tuberculosis patients: A report of three cases

Guiqing He et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Letter Medicine, General & Internal

Considering BCG vaccination to reduce the impact of COVID-19

Nigel Curtis et al.

LANCET (2020)

Article Medicine, General & Internal

Remdesivir for the Treatment of Covid-19-Final Report

John H. Beigel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Mild or Moderate Covid-19

Rajesh T. Gandhi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Public, Environmental & Occupational Health

Economic Consequences of the COVID-19 Outbreak: the Need for Epidemic Preparedness

Anton Pak et al.

FRONTIERS IN PUBLIC HEALTH (2020)

Review Biochemical Research Methods

A comprehensive review of COVID-19 characteristics

Hanie Esakandari et al.

BIOLOGICAL PROCEDURES ONLINE (2020)

Article Biochemistry & Molecular Biology

TCR-like domain antibody against Mycobacterium tuberculosis (Mtb) heat shock protein antigen presented by HLA-A*11 and HLA-A*24

Sylvia Annabel Dass et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Review Microbiology

Advances in Molecular Diagnosis of Tuberculosis

Emily MacLean et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2020)

Article Public, Environmental & Occupational Health

Case Report: Coronavirus Disease and Pulmonary Tuberculosis in Patients with Human Immunodeficiency Virus: Report of Two Cases

Luis Arthur Brasil Gadelha Farias et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2020)

Article Biochemistry & Molecular Biology

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

Evangelos J. Giamarellos-Bourboulis et al.

Meeting Abstract Critical Care Medicine

REACTIVATION TB WITH SEVERE COVID-19

Natasha Garg et al.

CHEST (2020)

Review Immunology

Vaccines for COVID-19

J. S. Tregoning et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2020)

Article Pharmacology & Pharmacy

COVID-19 Clinical Diagnostics and Testing Technology

Cindy H. Chau et al.

PHARMACOTHERAPY (2020)

Letter Infectious Diseases

COVID-19 and TB co-infection - 'Finishing touch in perfect recipe to 'severity' or 'death'

Rohit Kumar et al.

JOURNAL OF INFECTION (2020)

Review Pharmacology & Pharmacy

COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management

Md. Farhad Hossain et al.

FRONTIERS IN PHARMACOLOGY (2020)

Editorial Material Public, Environmental & Occupational Health

GeneXpert for the diagnosis of COVID-19 in LMICs

Niaina Rakotosamimanana et al.

LANCET GLOBAL HEALTH (2020)

Article Public, Environmental & Occupational Health

The case of pulmonary tuberculosis with COVID-19 in an Indian male-a first of its type case ever reported from South Asia

Sankalp Yadav et al.

PAN AFRICAN MEDICAL JOURNAL (2020)

Article Medicine, General & Internal

COVID-19 and Tuberculosis Coinfection in a 51-Year-Old Taxi Driver in Mexico City

Jose Arturo Martinez Orozco et al.

AMERICAN JOURNAL OF CASE REPORTS (2020)

Review Critical Care Medicine

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

Wentao Ni et al.

CRITICAL CARE (2020)

Review Immunology

Monoclonal Antibodies in Cancer Therapy

David Zahavi et al.

ANTIBODIES (2020)

Article Respiratory System

COVID-19 in a patient with active tuberculosis: A rare case-report

Fahad Faqihi et al.

RESPIRATORY MEDICINE CASE REPORTS (2020)

Article Medicine, General & Internal

One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis

S. Swindells et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Respiratory System

The global prevalence of latent tuberculosis: a systematic review and meta-analysis

Adam Cohen et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Review Immunology

A Case for Antibodies as Mechanistic Correlates of Immunity in Tuberculosis

Jeffrey Y. Kawahara et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques

Karin Dijkman et al.

NATURE MEDICINE (2019)

Review Pathology

Adoptive cellular therapies: the current landscape

Maartje W. Rohaan et al.

VIRCHOWS ARCHIV (2019)

Article Public, Environmental & Occupational Health

Potential effect of age of BCG vaccination on global paediatric tuberculosis mortality: a modelling study

Partho Roy et al.

LANCET GLOBAL HEALTH (2019)

Review Pediatrics

Tuberculosis and HIV-An Update on the Cursed Duet in Children

Samantha H. -L. Fry et al.

FRONTIERS IN PEDIATRICS (2019)

Review Medicine, General & Internal

The Diagnosis and Treatment of Tuberculosis

Isabelle Suarez et al.

DEUTSCHES ARZTEBLATT INTERNATIONAL (2019)

Article Public, Environmental & Occupational Health

Prevalence of Malaria and TB Coinfection at a National Tuberculosis Treatment Centre in Uganda

Joseph Baruch Baluku et al.

JOURNAL OF TROPICAL MEDICINE (2019)

Review Respiratory System

Tuberculosis vaccines: Opportunities and challenges

Bingdong Zhu et al.

RESPIROLOGY (2018)

Review Immunology

Development of tuberculosis vaccines in clinical trials: Current status

Patricia Mendez-Samperio

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2018)

Article Immunology

Antibodies and tuberculosis: finally coming of age?

Hao Li et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Review Medicine, General & Internal

The cursed duet today: Tuberculosis and HIV-coinfection

Simon Tiberi et al.

PRESSE MEDICALE (2017)

Article Multidisciplinary Sciences

Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis

Hao Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Infectious Diseases

Diversity and evolution of drug resistance mechanisms in Mycobacterium tuberculosis

Mashael Al-Saeedi et al.

INFECTION AND DRUG RESISTANCE (2017)

Review Immunology

Antibody therapies for the prevention and treatment of viral infections

Georgina Salazar et al.

NPJ VACCINES (2017)

Review Pediatrics

Non-specific effects of vaccines: plausible and potentially important, but implications uncertain

Andrew J. Pollard et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2017)

Article Medicine, Research & Experimental

Clinical Aspects of Adult Tuberculosis

Robert Loddenkemper et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2016)

Review Oncology

T cell receptor mimic antibodies for cancer therapy

Leonid Dubrovsky et al.

ONCOIMMUNOLOGY (2016)

Review Toxicology

Antibiotic resistance mechanisms in M-tuberculosis: an update

Liem Nguyen

ARCHIVES OF TOXICOLOGY (2016)

Review Immunology

Antibodies and tuberculosis

Ashley J. Jacobs et al.

TUBERCULOSIS (2016)

Article Multidisciplinary Sciences

T-cell activation is an immune correlate of risk in BCG vaccinated infants

Helen A. Fletcher et al.

NATURE COMMUNICATIONS (2016)

Review Microbiology

The Progress of Therapeutic Vaccination with Regard to Tuberculosis

Pere-Joan Cardona

FRONTIERS IN MICROBIOLOGY (2016)

Article Immunology

T regulatory cells: Achilles' heel of Mycobacterium tuberculosis infection?

Om Parkash et al.

IMMUNOLOGIC RESEARCH (2015)

Article Medicine, Research & Experimental

Tuberculosis and HIV Coinfection

Judith Bruchfeld et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2015)

Article Chemistry, Multidisciplinary

Fate of inhaled monoclonal antibodies after the deposition of aerosolized particles in the respiratory system

L. Guilleminault et al.

JOURNAL OF CONTROLLED RELEASE (2014)

Review Biology

The ongoing challenge of latent tuberculosis

H. Esmail et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014)

Article Microbiology

Functions of Antibodies

Donald N. Forthal

MICROBIOLOGY SPECTRUM (2014)

Review Microbiology

Antibody-Mediated Immunity against Tuberculosis: Implications for Vaccine Development

Jacqueline M. Achkar et al.

CELL HOST & MICROBE (2013)

Review Hematology

The Biology of Mycobacterium Tuberculosis Infection

Giovanni Delogu et al.

MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES (2013)

Article Biochemical Research Methods

Expression of high-affinity human antibody fragments in bacteria

Romain Rouet et al.

NATURE PROTOCOLS (2012)

Review Immunology

Escape from the phagosome: the explanation for MHC-I processing of mycobacterial antigens?

Melanie J. Harriff et al.

FRONTIERS IN IMMUNOLOGY (2012)

Article Infectious Diseases

Current management options for latent tuberculosis: a review

David Holland et al.

Infection and Drug Resistance (2012)

Review Immunology

The immunological life cycle of tuberculosis

Joel D. Ernst

NATURE REVIEWS IMMUNOLOGY (2012)

Review Microbiology

Mycobacterium tuberculosis: success through dormancy

Martin Gengenbacher et al.

FEMS MICROBIOLOGY REVIEWS (2012)

Review Immunology

Pathogenesis, Immunology, and Diagnosis of Latent Mycobacterium tuberculosis Infection

Suhail Ahmad

CLINICAL & DEVELOPMENTAL IMMUNOLOGY (2011)

Article Infectious Diseases

Immunosuppressive monoclonal antibodies: current and next generation

D. Focosi et al.

CLINICAL MICROBIOLOGY AND INFECTION (2011)

Editorial Material Medicine, General & Internal

The BCG World Atlas: A Database of Global BCG Vaccination Policies and Practices

Alice Zwerling et al.

PLOS MEDICINE (2011)

Review Chemistry, Multidisciplinary

Inhaled Drug Delivery for Tuberculosis Therapy

Pavan Muttil et al.

PHARMACEUTICAL RESEARCH (2009)

Review Biochemistry & Molecular Biology

Mechanisms of action of isoniazid

Graham S. Timmins et al.

MOLECULAR MICROBIOLOGY (2006)

Article Immunology

Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies

S de Vallière et al.

INFECTION AND IMMUNITY (2005)

Article Immunology

Severe acute respiratory syndrome and pulmonary tuberculosis

JGH Low et al.

CLINICAL INFECTIOUS DISEASES (2004)

Review Microbiology

Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence

I Smith

CLINICAL MICROBIOLOGY REVIEWS (2003)

Review Immunology

How can immunology contribute to the control of tuberculosis?

SHE Kaufmann

NATURE REVIEWS IMMUNOLOGY (2001)

Article Allergy

Transmission of IgA and IgG monoclonal antibodies to mucosal fluids following intranasal or parenteral delivery

G Falero-Diaz et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2000)