Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.798214
Keywords
beta-glucans; CLR; inflammation; Pneumocystis; pneumonia
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Funding
- National Heart, Lung, and Blood Institute [R01-HL62150-100]
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Pneumocystis jirovecii is a common fungal pathogen in immunocompromised individuals, causing significant host immune response driven by cell wall components. These components interact with CLRs, leading to activation of proinflammatory signaling pathways. This minireview summarizes known CLR/Pneumocystis interactions.
Pneumocystis jirovecii is one of the most common fungal pathogens in immunocompromised individuals. Pneumocystis jirovecii pneumonia (PJP) causes a significant host immune response that is driven greatly by the organism's cell wall components including beta-glucans and major surface glycoprotein (Msg). These ligands interact with a number of C-type lectin receptors (CLRs) leading to downstream activation of proinflammatory signaling pathways. This minireview provides a brief overview summarizing known CLR/Pneumocystis interactions.
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