4.8 Article

Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 Vaccination

Related references

Note: Only part of the references are listed.
Editorial Material Geriatrics & Gerontology

Efficacy and safety of COVID-19 vaccines in older people

Roy L. Soiza et al.

Summary: The safety and efficacy of COVID-19 vaccines in older people are crucial for their success, but there is currently a lack of data. While some Phase III trials have made efforts to recruit older people, those with co-morbidities and frailty have still been largely excluded. Older people, their carers, and healthcare professionals will need to make decisions on vaccination acceptance based on limited evidence.

AGE AND AGEING (2021)

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

Article Geriatrics & Gerontology

The impact of immuno-aging on SARS-CoV-2 vaccine development

Jennifer Connors et al.

Summary: The SARS-CoV-2 pandemic has been particularly deadly for older adults and those with compromised immune systems, while the global population of older people is increasing significantly. Aging is linked with immune function decline and chronic inflammation activation, leading to enhanced viral susceptibility. Focusing on novel vaccine platforms and adjuvant systems for older adults is crucial for improving vaccination efforts.

GEROSCIENCE (2021)

Review Biotechnology & Applied Microbiology

Emerging concepts in the science of vaccine adjuvants

Bali Pulendran et al.

Summary: Adjuvants are vaccine components that enhance the immune response. Recent advances in understanding the molecular mechanisms and systems vaccinology have revitalized the science and development of novel adjuvants for use in vaccines against COVID-19 and future pandemics.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Pharmacology & Pharmacy

Targeting natural killer cells to enhance vaccine responses

Andrew Cox et al.

Summary: Vaccination is crucial for global health, but some microbial threats remain resistant to past vaccine efforts due to inefficient memory T and B cell responses or the need to stimulate non-conventional forms of immunological memory. NK cells have emerged as key regulators of vaccine-elicited responses and memory cells contributing to pathogen control, with potential methods discussed for modulating NK cell functions to enhance vaccine success.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

Article Multidisciplinary Sciences

Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients

Maria Clara Saad Menezes et al.

Summary: This study found that in COVID-19 patients, the severe cases group had lower expression of TLR3 and overexpression of TLR4 when compared to the mild cases group.

SCIENTIFIC REPORTS (2021)

Review Immunology

Targeting Inflammation and Immunosenescence to Improve Vaccine Responses in the Elderly

Branca Pereira et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People

Anna Julia Pietrobon et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Review Immunology

Vaccination in the elderly: The challenge of immune changes with aging

Annalisa Ciabattini et al.

SEMINARS IN IMMUNOLOGY (2018)

Review Immunology

Vaccinating for natural killer cell effector functions

Helen R. Wagstaffe et al.

CLINICAL & TRANSLATIONAL IMMUNOLOGY (2018)

Article Immunology

Vaccine development: From concept to early clinical testing

Anthony L. Cunningham et al.

VACCINE (2016)

Review Immunology

Boosting vaccine efficacy the natural (killer) way

Carolyn E. Rydyznski et al.

TRENDS IN IMMUNOLOGY (2015)

Article Medicine, General & Internal

Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults

Carlos A. DiazGranados et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Immunology

Vaccine strategies to enhance immune responses in the aged

Julie S. Lefebvre et al.

CURRENT OPINION IN IMMUNOLOGY (2013)

Review Immunology

The history of MF59 (R) adjuvant: a phoenix that arose from the ashes

Derek T. O'Hagan et al.

EXPERT REVIEW OF VACCINES (2013)

Article Cell Biology

A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people

Giuseppina Colonna-Romano et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2009)