Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.738762
Keywords
CD8(+) Tc1; Tc17; T regs; TRM; Crohn's disease; ulcerative colitis; IBD
Categories
Funding
- FORUN Research Program
- Rostock University Medical Center (FORUN project [889023]
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Studies on the role of CD8(+) T cells in inflammatory bowel disease have shown contradictory outcomes, possibly due to the heterogeneity of the cells. Different subsets of CD8(+) T cells, such as Tc1 and Tc17 cells, may play a role in the pathogenesis of IBD. Regulatory CD8(+) T cells are abundant at sites of inflammation and can exhibit pro-inflammatory features.
CD8(+) T cells are involved in the pathogenesis of inflammatory bowel disease (IBD), a complex multifactorial chronic disease. Here, we present an overview of the current research with the controversial findings of CD8(+) T cell subsets and discuss some possible perspectives on their therapeutic value in IBD. Studies on the role of CD8(+) T cells in IBD have contradictory outcomes, which might be related to the heterogeneity of the cells. Recent data suggest that cytotoxic CD8(+) T cells (Tc1) and interleukin (IL) 17-producing CD8(+) (Tc17) cells contribute to the pathogenesis of IBD. Moreover, subsets of regulatory CD8(+) T cells are abundant at sites of inflammation and can exhibit pro-inflammatory features. Some subsets of tissue resident memory CD8(+) T cells (Trm) might be immunosuppressant, whereas others might be pro-inflammatory. Lastly, exhausted T cells might indicate a positive outcome for patients. The function and plasticity of different subsets of CD8(+) T cells in health and IBD remain to be further investigated in a challenging field due to the limited availability of mucosal samples and adequate controls.
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