Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.761920
Keywords
Tbx21; Eomes; Th1; tumor immunology; immunotherapy
Categories
Funding
- National Key R&D Program of China [2020YFA0710802]
- Natural Science Foundation of China [82071768]
- Natural Science Foundation of Guangdong Province [2019A1515011412]
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T-bet is a critical transcription factor that regulates the development, maturation, and function of NK cells, playing a role in immune surveillance and defense against infections, inflammation, autoimmune diseases, and tumors.
Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-gamma, IL-12, IL-15 and IL-21 through the respective cytokine receptors and downstream JAK/STATs or PI3K-AKT-mTORC1 signaling pathways. In this review, we aim to discuss the expression and regulation of T-bet in NK cells, the role of T-bet in mouse NK cell development, maturation, and function, as well as the role of T-bet in acute, chronic infection, inflammation, autoimmune diseases and tumors.
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