Synthesis, Spectroscopic, and Biological Assessments on Some New Rare Earth Metal Adrenaline Adducts

Adrenaline (Adr) reacts with chlorides of Y3+, Ce3+, Nd3+ and Sm3+ in methanol at 60 degrees C to yield metal ion adducts of definite composition. These compounds are characterized by elemental analyses, molar conductivity, UV-Vis., H-1-NMR, Raman laser, scanning electron microscopy, energy-dispersive X-ray spectroscopy (EDX), and mid infrared spectral measurement investigations. The adducts are found to have the formulae [Y-2(Adr)(2)(H2O)(8)]Cl-3.8H(2)O, [Ce(Adr)(2)(H2O)(2)]Cl-3.10H(2)O, [Nd(Adr)(2)(H2O)(2)]Cl-3.6H(2)O, and [Sm(Adr)(2)(H2O)(2)]Cl-3.12H(2)O, respectively. The two phenolic groups of the catechol moiety are linked to central metal ions based on the infrared and Raman laser spectra. The new compounds were tested against five gram-positive and two-gram negative bacteria, in addition to two Aspergillus strains. Metal adducts were shown to have stronger antibacterial and antifungal properties than free adrenaline compounds.

Automated summary

Adrenaline reacts with metal chlorides in methanol to form metal ion adducts with clear composition. These adducts exhibit stronger antibacterial and antifungal properties compared to free adrenaline compounds, with their chemical structures and compositions analyzed in detail.