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Summary: The genomic complexity of multiple myeloma is reflected in the variable clinical presentation of patients, making genome-wide studies a reasonable alternative for identifying critical genomic lesions. The most frequently detected alterations in a Portuguese cohort of multiple myeloma patients were identified, with some having known prognostic value while others remain with unknown but potentially significant implications for clinical practice. Further assessment of these genomic alterations as possible biomarkers is warranted.
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Hira S. Mian et al.
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Liliana Belgioia et al.
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Summary: circRNAs are a class of interesting and conserved single-stranded RNA molecules that play important roles in various biological processes, especially in microRNA sponges, gene splicing and transcription regulation, RNA-binding protein sponges, and protein/peptide translation. They are involved in various human diseases, particularly cancers, and may serve as better predictive biomarkers and therapeutic targets for cancer treatment.
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Immunology
Xingyu Zhai et al.
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Qing Huang et al.
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Huapeng Lin et al.
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Weijie Wang et al.
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Summary: The study found that more than half of cancer patients visiting emergency departments were admitted to the hospital, with a mortality rate of 16.1%. Lung cancer, liver cancer, and leukemia/multiple myeloma had the highest mortality rates. Understanding the differences in prevalence and outcomes of oncological emergencies by cancer type is crucial for improving patient care.
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