Journal
APPLIED SCIENCES-BASEL
Volume 12, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/app12020760
Keywords
PACAP; eye; cornea; injury; repair
Categories
Funding
- PIAno di inCEntivi per la RIcerca di Ateneo 2020/2022 Linea di Intervento 3 Starting Grant REPAIR, University of Catania
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PACAP is a neuropeptide with cytoprotective effects in the eye, particularly in the cornea, and may play a role in physiological or pathological conditions in the eye.
Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is a neuropeptide with widespread distribution throughout the central and peripheral nervous system as well as in many other peripheral organs. It plays cytoprotective effects mediated mainly through the activation of specific receptors. PACAP is known to play pleiotropic effects on the eye, including the cornea, protecting it against different types of insult. This review firstly provides an overview of the anatomy of the cornea and summarizes data present in literature about PACAP's role in the eye and, in particular, in the cornea, either in physiological or pathological conditions.
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