Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 22, Pages -Publisher
MDPI
DOI: 10.3390/app112211049
Keywords
osteoarthritis; knee; arthroplasty; intraarticular injections; mesenchymal stem cells; platelet rich plasma; clinical trials; pain
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Funding
- Victor Babes University of Medicine and Pharmacy of Timisoara
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The study found that ongoing studies for knee osteoarthritis represent a small fraction of registered clinical trials, but they make up over a quarter of all knee trials and over two thirds of all osteoarthritis studies. These studies primarily focus on arthroplasty and intraarticular injections for treatment.
We aimed to evaluate potential new treatments for knee osteoarthritis (OA). The National Institute of Health ClinicalTrials.gov database was searched for Osteoarthritis, Knee . We found 565 ongoing interventional studies with a total planned enrollment of 111,276 subjects. Ongoing studies for knee OA represent a very small fraction of the registered clinical trials, but they are over a quarter of all knee trials and over two thirds of all OA studies. The most researched topic was arthroplasty, with aspects such as implant design changes, cementless fixation, robotic guidance, pain management, and fast track recovery. Intraarticular injections focused on cell therapies with mesenchymal stem cells sourced from adipose tissue, bone marrow, or umbilical cord. We could see the introduction of the first disease modifying drugs with an impact on knee OA, as well as new procedures such as geniculate artery embolization and geniculate nerve ablation.
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