Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/app11199336
Keywords
polysorbate; surfactants; blood-brain barrier; cancer therapy; drug delivery
Categories
Funding
- Research Assistance Program (2019) in the Incheon National University
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2020R1I1A1A01071074]
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Polysorbates (PSs) are synthetic nonionic surfactants used as emulsifiers and stabilizers in drug formulations and food additives. Recent developments in PS-based drug formulations, particularly targeting brain delivery, showcase the potential of PS as effective drug carriers.
Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives. Recently, various PS-based formulations have been developed for safe and efficient drug delivery. This review introduces the general features of PSs and PS-based drug carriers, summarizes recent progress in the development of PS-based drug formulations, and discusses the physicochemical properties, biological safety, P-glycoprotein inhibitory properties, and therapeutic applications of PS-based drug formulations. Additionally, recent advances in brain-targeted drug delivery using PS-based drug formulations have been highlighted. This review will help researchers understand the potential of PSs as effective drug formulation agents.
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