Probiotic Molecules That Inhibit Inflammatory Diseases

Featured Application Exopolysaccharide from Bacillus subtilis induces an anti-inflammatory response that protects mice from several inflammatory diseases, including enteric and blood-borne pathogens, allergic eosinophilia, and graft versus host disease. This EPS, designated EPSBs, has potential as a therapeutic for inflammatory diseases in humans. Consumption of probiotics for health purposes has increased vastly in the past few decades, and yet the scientific evidence to support health benefits from probiotics is only beginning to emerge. As more probiotics are studied, we are beginning to understand the mechanisms of action by which they benefit human health, as well as to identify the bacterial molecules responsible for these benefits. A new era of therapeutics is on the horizon in which purified molecules from probiotics will be used to prevent and treat diseases. In this review, we summarize the active molecules from probiotic bacteria that have been shown to affect innate and adaptive immunity and have health benefits in experimental settings. We focus particularly on the cellular and molecular mechanisms of the probiotic Bacillus subtilis and its active molecule, exopolysaccharide (ESPBs).

Automated summary

This study summarizes the active molecules from probiotic bacteria that affect immunity and have health benefits, with a particular focus on the probiotic Bacillus subtilis and its active molecule, exopolysaccharide (ESPBs).