Journal
APPLIED SCIENCES-BASEL
Volume 12, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/app12010336
Keywords
Fourier transform infrared microspectroscopy; infrared synchrotron radiation; human cells; proton irradiation; hadron therapy
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Fourier transform infrared microspectroscopy using a synchrotron radiation source has great potential in studying the ionizing radiation effects on human cells. It has been successfully employed in shedding light on cell processes exposed to hadron therapy, and can contribute to the improvement of cancer treatment strategies.
Fourier transform infrared microspectroscopy using a synchrotron radiation source (SR-mu FTIR) has great potential in the study of the ionizing radiation effects of human cells by analyzing the biochemical changes occurring in cell components. SR-mu FTIR spectroscopy has been usefully employed in recent years in some seminal work devoted to shedding light on processes occurring in cells treated by hadron therapy, that is, radiotherapy with charged heavy particles (mainly protons and carbon ions), which is gaining popularity as a cancer treatment modality. These studies are particularly useful for increasing the effectiveness of radiotherapy cancer treatments with charged particles that can offer significant progress in the treatment of deep-seated and/or radioresistant tumors. In this paper, we present a concise revision of these studies together with the basic principles of mu FTIR spectroscopy and a brief presentation of the main characteristics of infrared SR sources. From the analysis of the literature regarding the SR-mu FTIR spectroscopy investigation on human cells exposed to proton beams, it is clearly shown that changes in DNA, protein, and lipid cell components are evident. In addition, this review points out that the potential offered by SR-mu FTIR in investigating the effects induced by charged particle irradiation have not been completely explored. This is a crucial point for the continued improvement of hadron therapy strategies.
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