Journal
APPLIED SCIENCES-BASEL
Volume 12, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/app12010328
Keywords
silicon on insulator; proton therapy; particle therapy; RBE; 3D detector; microdosimetry
Categories
Funding
- Australian Research Council [DP 170102273, DP170102423]
- European Space Agency (ESA) [4000112670/14/NL/HK]
- Australian Government Research Training Program Scholarship
- Australian Institute of Nuclear Science and Engineering (AINSE)
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The Centre for Medical Radiation Physics introduced the concept of Silicon On Insulator (SOI) microdosimeters with 3-Dimensional (3D) cylindrical sensitive volumes (SVs) mimicking the dimensions of cells in an array. Several designs of high-definition 3D SVs fabricated using 3D MEMS technology were implemented. The SVs were used to evaluate the relative biological effectiveness (RBE) of heavy ions and protons delivered by different particle therapy centers.
The Centre for Medical Radiation Physics introduced the concept of Silicon On Insulator (SOI) microdosimeters with 3-Dimensional (3D) cylindrical sensitive volumes (SVs) mimicking the dimensions of cells in an array. Several designs of high-definition 3D SVs fabricated using 3D MEMS technology were implemented. 3D SVs were fabricated in different sizes and configurations with diameters between 18 and 30 mu m, thicknesses of 2-50 mu m and at a pitch of 50 mu m in matrices with volumes of 20 x 20 and 50 x 50. SVs were segmented into sub-arrays to reduce capacitance and avoid pile up in high-dose rate pencil beam scanning applications. Detailed TCAD simulations and charge collection studies in individual SVs have been performed. The microdosimetry probe (MicroPlus) is composed of the silicon microdosimeter and low-noise front-end readout electronics housed in a PMMA waterproof sheath that allows measurements of lineal energies as low as 0.4 keV/mu m in water or PMMA. Microdosimetric quantities measured with SOI microdosimeters and the MicroPlus probe were used to evaluate the relative biological effectiveness (RBE) of heavy ions and protons delivered by pencil-beam scanning and passive scattering systems in different particle therapy centres. The 3D detectors and MicroPlus probe developed for microdosimetry have the potential to provide confidence in the delivery of RBE optimized particle therapy when introduced into routine clinical practice.
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