Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 21, Pages -Publisher
MDPI
DOI: 10.3390/app11219941
Keywords
human aorta; abdominal aortic aneurysm; intraluminal thrombus; computational fluid dynamics; 3D reconstruction
Categories
Funding
- College of Applied Medical Sciences Research Centre
- Deanship of Scientific Research at King Saud University
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This research utilized computer modeling to study the impact of intraluminal thrombus (ILT) on abdominal aortic aneurysm (AAA) rupture, and found that ILT does not lead to local hypoxia as previously theorized.
The role of intraluminal thrombus (ILT) in the rupture of abdominal aortic aneurysms (AAA) is controversial, and it is unclear whether it increases or decreases the risk of rupture. This research aims to find a clear answer to this question. Previous computer modelling suggests that an ILT lowers oxygen dissemination to the AAA wall, contributing to wall thinning. The methodology used in this study determines the amount of oxygen reaching the aneurysm wall after passing through the ILT by using the porous nature of the ILT to recreate the condition as closely as feasible. Using computed tomographic images, patient-specific three-dimensional (3D) AAA geometries were recreated. Modelling blood and oxygen flow in AAA was obtained using a computational fluid dynamics (CFD) approach. Our findings indicated that the oxygen volume percentage had completely reached the aneurysm wall. Only at the inlet and outflow did the greatest wall shear stress (WSS) occur, with a significant drop in the central region of the aneurysm wall. CFD was used to calculate the velocity, pressure, and WSS of aortic blood flow. ILT had no effect on oxygen flow to the aneurysm wall, disproving the theory that it produces local hypoxia.
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