Journal
APPLIED SCIENCES-BASEL
Volume 11, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/app11209532
Keywords
model predictive control; moving horizon flux estimation; metabolic network models; bioprocess optimization; online state and parameter estimation; dynamic metabolic flux analysis
Categories
Funding
- KU Leuven Center-of-Excellence Optimization in Engineering (OPTEC)
- Fund for Scientific Research Flanders (FWO) [G086318N, G0B4121N]
- European Commission [619864-EPP-1-2020-1-BE-EPPKA1-JMD-MOB]
- European Unions Horizon 2020 Research and Innovation programme under the Marie Sklodowska-Curie Grant [N956126]
- FWO [G0B4121N]
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Bioprocesses are used to produce high added value products, which are complex and governed by intricate mechanisms. Current bioprocess control solely focuses on material balances, missing opportunities to operate more sustainably with available process knowledge. This article presents a metabolic network-based model predictive control method, utilizing a combined moving horizon-model predictive control strategy to optimize bioprocesses.
Bioprocesses are increasingly used for the production of high added value products. Microorganisms are used in bioprocesses to mediate or catalyze the necessary reactions. This makes bioprocesses highly nonlinear and the governing mechanisms are complex. These complex governing mechanisms can be modeled by a metabolic network that comprises all interactions within the cells of the microbial population present in the bioprocess. The current state of the art in bioprocess control is model predictive control based on the use of macroscopic models, solely accounting for substrate, biomass, and product mass balances. These macroscopic models do not account for the underlying mechanisms governing the observed process behavior. Consequently, opportunities are missed to fully exploit the available process knowledge to operate the process in a more sustainable manner. In this article, a procedure is presented for metabolic network-based model predictive control. This procedure uses a combined moving horizon-model predictive control strategy to monitor the flux state and optimize the bioprocess under study. A CSTR bioreactor model has been combined with a small-scale metabolic network to illustrate the performance of the presented procedure.
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