Journal
ADVANCED SCIENCE
Volume 9, Issue 4, Pages -Publisher
WILEY
DOI: 10.1002/advs.202102924
Keywords
2D materials; evanescent wave; fluorescence resonance energy transfer; optical biosensor; surface plasmon resonance
Categories
Funding
- Heilongjiang Natural Science Foundation [JJ2019LH1509]
- National Natural Science Foundation [61875043]
- 111 Project of Harbin Engineering University [B13015]
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The combination of 2D materials and optical biosensors has unique optical properties, advantages in sensitivity and detection limit compared to traditional sensors, making them suitable for applications in biological imaging, food safety, pollution prevention/control, and biological medicine.
The combination of 2D materials and optical biosensors has become a hot research topic in recent years. Graphene, transition metal dichalcogenides, black phosphorus, MXenes, and other 2D materials (metal oxides and degenerate semiconductors) have unique optical properties and play a unique role in the detection of different biomolecules. Through the modification of 2D materials, optical biosensor has the advantages that traditional sensors (such as electrical sensing) do not have, and the sensitivity and detection limit are greatly improved. Here, optical biosensors based on different 2D materials are reviewed. First, various detection methods of biomolecules, including surface plasmon resonance (SPR), fluorescence resonance energy transfer (FRET), and evanescent wave and properties, preparation and integration strategies of 2D material, are introduced in detail. Second, various biosensors based on 2D materials are summarized. Furthermore, the applications of these optical biosensors in biological imaging, food safety, pollution prevention/control, and biological medicine are discussed. Finally, the future development of optical biosensors is prospected. It is believed that with their in-depth research in the laboratory, optical biosensors will gradually become commercialized and improve people's quality of life in many aspects.
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