Journal
ACS BIOMATERIALS SCIENCE & ENGINEERING
Volume 8, Issue 2, Pages 786-800Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c01279
Keywords
bioelastomer; polymer-clay nanocomposite; hydrogel; tissue engineering; drug delivery
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Funding
- University of Sheffield
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This study presents the design and synthesis of a poly(glycerol sebacate)-based polyurethane-clay nanocomposite hydrogel system with controllable mechanical, swelling, drug release, and biodegradation behaviors. The nanocomposite hydrogels exhibit higher water swelling ratios, complex mechanical deformations, and improved mechanical properties with the addition of a small amount of clay. The selective drug loading capacity, sustained release behavior, and tunable degradation rate by the clay content in the nanocomposite hydrogels are also demonstrated.
Elastomeric hydrogels are promising in soft tissue applications due to their biomimetic mechanical and physical behaviors. In this study, we design and synthesize a poly(glycerol sebacate)-based polyurethane-clay nanocomposite hydrogel system with controllable mechanical, swelling, drug release, and biodegradation behaviors. The polymer-clay nanocomposites are synthesized by in situ polymerization in the presence of a solvent, which facilitates the dispersion of clay within the polymer matrix and their bonding. The nanocomposite hydrogels exhibit higher water swelling ratios in comparison to the neat polymer. The fully swollen hydrogels are capable of enduring complex mechanical deformations such as stretching and knotting, while the tensile moduli of the hydrogels mimic various soft tissues in human body. The mechanical behavior of hydrogels is significantly enhanced by the addition of no more than 3 phr clay, showing higher stiffness, strength, ductility, and toughness. The drug loading and release behavior of the hydrogels is investigated with three model drugs, showing selective drug loading capacity and sustained release, based on the Coulombic interaction between the clay and drug molecules. Biodegradation tests under a simulated body condition reveal a highly tunable degradation rate by the clay content in the nanocomposite hydrogels. Good cytocompatibility by the cell metabolic assay with mouse fibroblasts in vitro is also demonstrated. Finally, three-dimensional microporous foam is manufactured as a proof-of-concept study.
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