4.6 Article

Impact of dialysis modality conversion on the health-related quality of life of peritoneal dialysis patients: a retrospective cohort study in China

Journal

PEERJ
Volume 9, Issue -, Pages -

Publisher

PEERJ INC
DOI: 10.7717/peerj.12793

Keywords

End-stage renal disease; Automated peritoneal dialysis; Continuous ambulatory peritoneal dialysis; Health-related quality of life; Dialysis modality conversion

Funding

  1. National Social Science Fund of China [17ZDA078]
  2. Scientific Research Project of Jiangsu Provincial Health Commission [H2017073]

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The study aimed to analyze the impact of converting dialysis modality on health-related quality of life among end-stage renal disease patients in China. The results showed that the group converting to automated peritoneal dialysis had higher scores in multiple subscales compared to before the conversion.
Background. To analyze the health-related quality of life associated with the conversion of dialysis modality among end-stage renal disease patients in China. Methods. Patients were recruited from hospitals and a dialysis center in Kunshan, China. Patients converting from continuous ambulatory peritoneal dialysis to automated peritoneal dialysis were recruited as the observation group (n=64), and patients continuing with continuous ambulatory peritoneal dialysis treatment were included in the control group (n = 64) after matching in this retrospective cohort study. Their health-related quality of life was measured using the kidney disease quality of life instrument in 2019 and 2020, respectively. Baseline socio-demographic characteristics and clinical data were collected in 2019. The before-and-after cross-group comparisons of subscale scores of two groups were conducted using a Student`s t-test. Multiple linear regression models were fitted to identify the factors associated with the change of each scale. Results. The health-related quality of life scores of the two groups was comparable in baseline, while the observation group had higher scores in Physical Component Summary (51.92 +/- 7.50), Kidney Disease Component Summary (81.21 +/- 8.41), Symptoms (90.76 +/- 6.30), Effects (82.86 +/- 11.42), and Burden (69.04 +/- 15.69) subscales after one year. In multivariate regression analysis, the change of Physical Component Summary was significantly associated with conversion to APD (beta =11:54, 95% CI [7.26-15.82]); the change of Mental Component Summary with higher education (beta = 95% CI [ and CCI (>2) (beta = 5:39, 95% CI [1.05-9.73]); the change of Kidney Disease Component Summary with conversion to APD (beta= 15:95, 95% CI [10.19-21.7]) and age (>60 years) (beta = 95% CI [the change of Symptoms with CCI (>2) (beta = 7:96, 95% CI [1.49- 14.44]); the change of Effects with conversion to APD (beta = 19:23, 95% CI [11.57- 26.88]); and the change of Burden with conversion to APD (beta = 22:40, 95% CI [13.46- 31.34]), age (>60 years) (beta = 95% CI [-22.59-1.65]), and higher education (beta = 95% CI [ -19.79-0.98]) Conclusions. The conversion of dialysis modality had a significant impact on the scores of most subscales. Patients converting from continuous ambulatory peritoneal dialysis

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