Journal
NANOPHOTONICS
Volume 11, Issue 6, Pages 1219-1230Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/nanoph-2021-0816
Keywords
biosensor; EIT; reversible; THz metasurfaces; whey protein
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Funding
- National Natural Science Foundation of China (NSFC) [61701434, 61735010, 61675147]
- Special Funding of the Taishan Scholar Project [tsqn201909150]
- Natural Science Foundation of Shandong Province [ZR2021MF014]
- National Key Research and Development Program of China [2017YFB1401203, 2017YFA0700202]
- Qingchuang Science and Technology Plan of Shandong Universities [2019KJN001]
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This article introduces a biosensor based on terahertz metasurfaces, consisting of a metasurface and a metal oxide semiconductor-like structure, which enables ultra-sensitive multidimensional detection. By varying the photoconductivity of the semiconductor-like structure, the biosensor can detect whey protein concentrations as low as 6.25 ng/mL, and significant variations in frequency, phase, and transmission amplitude were observed for different protein concentrations. Reversible biosensing in the terahertz region was also achieved by applying lasers with different wavelengths.
Biosensors based on terahertz (THz) metasurfaces have recently attracted widespread attention. However, few have been reported so far because it is a challenge to achieve ultrasensitive multidimensional detection in the THz spectrum. Here, we propose a novel THz biosensor that consists of a metasurfaces and a metal oxide semiconductor-like structure (MOSLS), which is based on patterned graphene-polyimide-perovskite. We varied the photoconductivity of the MOSLS via the electrostatic doping effect. The biosensor could detect whey protein down to a concentration limit of 6.25 ng/mL. Significant responses in frequency, phase, and transmission amplitude were all detected for different protein concentrations. The transmission value difference, frequency shift, and phase difference increased with the concentration of whey protein, clearly demonstrating multidimensional biosensing. Moreover, by applying lasers with different wavelengths, we have realized reversible biosensing in THz region for the first time. These results are very promising for applications of THz metasurfaces in the field of biosensing.
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